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@inproceedings{858655, author = {Adam, Jan and Kříž, Zdeněk and Prokop, Martin and Wimmerová, Michaela and Koča, Jaroslav}, address = {Brno}, booktitle = {Cukrblik 2009}, keywords = {lectins; docking; computational chemistry; thermodynamics}, language = {eng}, location = {Brno}, isbn = {978-80-210-4831-7}, pages = {11-11}, publisher = {Masarykova Univerzita}, title = {Analyzing and modelling thermodynamics; the key to lectin engineering}, year = {2009} }
TY - JOUR ID - 858655 AU - Adam, Jan - Kříž, Zdeněk - Prokop, Martin - Wimmerová, Michaela - Koča, Jaroslav PY - 2009 TI - Analyzing and modelling thermodynamics; the key to lectin engineering PB - Masarykova Univerzita CY - Brno SN - 9788021048317 KW - lectins KW - docking KW - computational chemistry KW - thermodynamics N2 - Thermodynamics is a basic driving force of all chemical processes, including those in the biomolecular chemistry. Not a single process can disobey its fundamental rules. The lectin-saccharide interaction is no exception, and as such, the understanding of the principles determining its behaviour greatly helps to elucidate the rules of the lectin-saccharide mediated processes in the nature, and, of course, also the ways of modifying them in the desired ways. Characterizing the thermodynamic behaviour of the molecules is nowadays a quite achievable feat, thanks to development on the instrumental field. Isothermal titration calorimeters requiring only small amounts of protein to provide thermodynamics information and coupled with surface plasmon resonance, a potent mean of kinetics analysis, obtaining a detailed image of the interaction becomes quite easily available. Moreover, the current computational capacity allows to perform sophisticated simulations and modelling of the biomolecular interactions. ER -
ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Michaela WIMMEROVÁ a Jaroslav KOČA. Analyzing and modelling thermodynamics; the key to lectin engineering. In \textit{Cukrblik 2009}. Brno: Masarykova Univerzita, 2009, s.~11. ISBN~978-80-210-4831-7.
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