ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Thomais CHATZIPAVLOU, Petros ZOTOS, Jaroslav KOČA a Michaela WIMMEROVÁ. CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY. In FEBS Journal. Oxford: Wiley-Blackwell, 2009, s. 12-13. ISSN 1742-464X. |
Další formáty:
BibTeX
LaTeX
RIS
@inproceedings{858660, author = {Adam, Jan and Kříž, Zdeněk and Prokop, Martin and Chatzipavlou, Thomais and Zotos, Petros and Koča, Jaroslav and Wimmerová, Michaela}, address = {Oxford}, booktitle = {FEBS Journal}, keywords = {lectin engineering; molecular modeling; thermodynamics}, language = {eng}, location = {Oxford}, pages = {12-13}, publisher = {Wiley-Blackwell}, title = {CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY}, year = {2009} }
TY - JOUR ID - 858660 AU - Adam, Jan - Kříž, Zdeněk - Prokop, Martin - Chatzipavlou, Thomais - Zotos, Petros - Koča, Jaroslav - Wimmerová, Michaela PY - 2009 TI - CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY PB - Wiley-Blackwell CY - Oxford KW - lectin engineering KW - molecular modeling KW - thermodynamics N2 - INTRODUCTION Pseudomonas aeruginosa is an opportunistic human pathogen, a bacterium capable of attacking individuals with lowered immunity barriers. It is e.g. responsible for lethal complications in patients with cystic fibrosis. The PAIIL lectin (a C type fucose-preferring lectin with sugar binding mediated by two calcium ions), produced by the bacterium plays a crucial role in the host pathogen interaction. Similar lectin sequences were found in other bacteria, displaying distinct differences in preference despite only small differences in structure of binding site. In vitro and in silico mutants were constructed in order to analyze the principles driving the sugar preference. METHODS Molecular docking was performed using the AUTODOCK and DOCK software. ER -
ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Thomais CHATZIPAVLOU, Petros ZOTOS, Jaroslav KOČA a Michaela WIMMEROVÁ. CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY. In \textit{FEBS Journal}. Oxford: Wiley-Blackwell, 2009, s.~12-13. ISSN~1742-464X.
|