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@article{858791,
author = {Uhlířová, Radka and Harničarová, Andrea and Galiová, Gabriela and Legartová, Soňa and Matula, Pavel and Fojtová, Miloslava and Vařecha, Miroslav and Amrichová, Jana and Vondráček, Jan and Kozubek, Stanislav and Bártová, Eva},
article_number = {5},
doi = {http://dx.doi.org/10.1002/jcb.22466},
keywords = {SUV39h;histone methyltransferases;telomeres;PML bodies;LMNA gene;epigenetics;chromatin structure;nuclear radial distributions;image analysis},
language = {eng},
issn = {0730-2312},
journal = {Journal of Cellular Biochemistry},
title = {SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement},
url = {http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract},
volume = {109},
year = {2010}
}
TY - JOUR
ID - 858791
AU - Uhlířová, Radka - Harničarová, Andrea - Galiová, Gabriela - Legartová, Soňa - Matula, Pavel - Fojtová, Miloslava - Vařecha, Miroslav - Amrichová, Jana - Vondráček, Jan - Kozubek, Stanislav - Bártová, Eva
PY - 2010
TI - SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement
JF - Journal of Cellular Biochemistry
VL - 109
IS - 5
SP - 915-926
EP - 915-926
SN - 07302312
KW - SUV39h;histone methyltransferases;telomeres;PML bodies;LMNA gene;epigenetics;chromatin structure;nuclear radial distributions;image analysis
UR - http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract
L2 - http://onlinelibrary.wiley.com/doi/10.1002/jcb.22466/abstract
N2 - Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency. These differences could be explained by differing levels of the telomerase subunit, TERT, in SUV39h- and LMNA-deficient fibroblasts. Taken together, our data show that SUV39h and A-type lamins likely play a key role in telomere maintenance and telomere nuclear architecture.
ER -
UHLÍŘOVÁ, Radka, Andrea HARNIČAROVÁ, Gabriela GALIOVÁ, Soňa LEGARTOVÁ, Pavel MATULA, Miloslava FOJTOVÁ, Miroslav VAŘECHA, Jana AMRICHOVÁ, Jan VONDRÁČEK, Stanislav KOZUBEK and Eva BÁRTOVÁ. SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement. \textit{Journal of Cellular Biochemistry}. 2010, vol.~109, No~5, p.~915-926. ISSN~0730-2312. Available from: https://dx.doi.org/10.1002/jcb.22466.
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