Detailed Information on Publication Record
2010
SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement
UHLÍŘOVÁ, Radka, Andrea HARNIČAROVÁ, Gabriela GALIOVÁ, Soňa LEGARTOVÁ, Pavel MATULA et. al.Basic information
Original name
SUV39h- and A-type Lamin-Dependent Telomere Nuclear Rearrangement
Authors
UHLÍŘOVÁ, Radka (203 Czech Republic), Andrea HARNIČAROVÁ (703 Slovakia), Gabriela GALIOVÁ (203 Czech Republic), Soňa LEGARTOVÁ (703 Slovakia), Pavel MATULA (203 Czech Republic, guarantor, belonging to the institution), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Miroslav VAŘECHA (203 Czech Republic, belonging to the institution), Jana AMRICHOVÁ (203 Czech Republic, belonging to the institution), Jan VONDRÁČEK (203 Czech Republic), Stanislav KOZUBEK (203 Czech Republic) and Eva BÁRTOVÁ (203 Czech Republic)
Edition
Journal of Cellular Biochemistry, 2010, 0730-2312
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.122
RIV identification code
RIV/00216224:14330/10:00051236
Organization unit
Faculty of Informatics
UT WoS
000276418900010
Keywords in English
SUV39h;histone methyltransferases;telomeres;PML bodies;LMNA gene;epigenetics;chromatin structure;nuclear radial distributions;image analysis
Tags
International impact, Reviewed
Změněno: 20/4/2012 09:41, RNDr. Pavel Šmerk, Ph.D.
Abstract
V originále
Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies. This association was increased by SUV39h deficiency and decreased by LMNA deficiency. These differences could be explained by differing levels of the telomerase subunit, TERT, in SUV39h- and LMNA-deficient fibroblasts. Taken together, our data show that SUV39h and A-type lamins likely play a key role in telomere maintenance and telomere nuclear architecture.
Links
| LC06027, research and development project |
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| LC535, research and development project |
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| MSM0021622415, plan (intention) |
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| 2B06052, research and development project |
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