Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA

HERMANN, Petr, Přemysl LUBAL, Jakub VANĚK and Miloš POLÁŠEK. Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA. In COST D38 Annual Workshop. 2009.

Basic information

• Original name: Thermodynamic and kinetic studies of lanthanide(III) complexes with mono(pyridine-N-oxide) analog of DOTA
• Name in Czech: Termodynamická a kinetická studia Ln(III) komplexů mono(pyridine-N-oxide) DOTA analogu
• Authors: HERMANN, Petr (203 Czech Republic, guarantor), Přemysl LUBAL (203 Czech Republic, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution) and Miloš POLÁŠEK (203 Czech Republic).
• Edition: COST D38 Annual Workshop, 2009.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Poland
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/09:00042951
• Organization unit: Faculty of Science
• Keywords in English: Macrocyclic ligands; Ln(III) complexes; MRI; thermodynamics; kinetics

Abstract

Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III) or Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Y(III) and Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) H4dota derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS). The mechanisms of complex formation (pH = 5.0-6.0, t = 25 degrees of Celsius, I = 0.1 M KCl) and acid-assisted complex dissociation (t = 25-70 degrees of Celsius, I = 3.0 M (Na,H)ClO4) were proposed. Achieved results can be used for fluorimetric determination of Ln(III) ions in mixture.

Abstract (in Czech)

Ln(III) komplexy H4dota a jeho derivátů jsou využívány v mnoha oblastech medicíny (např. kovové komplexy radioizotopů jako 90Y, 153Sm, 166Ho, 177Lu v nukleární medicíně, Gd(III) komplexy jako MRI kontrastní látky, Eu(III) nebo Tb(III) komplexy jako luminescenční sondy). V tomto příspěvku byly studovány termodynamické a kinetické vlastnosti Y(III) a Ln(III) komplexů (Ln = Ce, Eu, Gd, Yb) mono(pyridin-N-oxid) H4dota derivátu pomocí molekulové absorpční a emisní spektroskopie (v UV/VIS oblasti, luminescence, TRFS). Byl navržen mechanismus vzniku komplexu (pH = 5.0-6.0, t = 25 st. C, I = 0.1 M KCl) a kysele katalyzovaný rozklad komplexu (t = 25-70 st. C, I = 3.0 M (Na,H)ClO4) byly navrženy. Dosažené výsledky lze využít pro fluorimetrické stanovení Ln(III) iontů ve směsi.

Links

• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)