Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives

LUBAL, Přemysl, Ivona SVOBODOVÁ, Josef PASULKA and Petr HERMANN. Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives. In COST D38 Annual Workshop. 2009.

Basic information

• Original name: Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives
• Name in Czech: Termodynamické a kinetické studium Cu(II) komplexů DOTA derivátů obsahující pendantní rameno s fosforem
• Authors: LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), Ivona SVOBODOVÁ (203 Czech Republic), Josef PASULKA (203 Czech Republic, belonging to the institution) and Petr HERMANN (203 Czech Republic).
• Edition: COST D38 Annual Workshop, 2009.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Poland
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/09:00042953
• Organization unit: Faculty of Science
• Keywords in English: Macrocyclic ligands; Cu(III) complexes; radioisotope diagnostics and therapy; thermodynamics; kinetics

Abstract

Bifunctional chelating agents (BFC) complexing copper(II) ion are utilized in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Therefore, it is necessary to know thermodynamic and kinetic properties (dissociation rate constants for estimation of kinetic inertness) of copper(II) complexes in order to find the best macrocyclic BFC for possible medical applications in vivo. In this work, the thermodynamic and kinetic properties of copper(II) complexes with macrocyclic ligands with acetic and phosphorus acid pendant arms were studied.

Abstract (in Czech)

Bifunkční chelatující činidla (BFC) complexující Cu(II) ion se používají v nukleární medicíně, např. jako radioizotopy v diagnostice (64Cu) nebo radioterapii (67Cu). BFC obsahuje strukturní motiv, který koordinuje kov (např. makrocyclus) připojený k biologicky aktivní molekule. Používané komplexy by měly vykazovat vysokou termodynamickou stabilitu a kinetickou inertnost za fyziologických podmínek. V této práci, termodynamické a kinetické vlastnsoti Cu(II) komplexů s makrocyklickými ligandy obsahující CH2COOh a P kyseliny na pendantních ramenech byly studovány.

Links

• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)