Detailed Information on Publication Record
2010
Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL
GIEBEL, S., B. STELLA-HOLOWIECKA, M. KRAWCZYK-KULIS, N. GÖKBUGET, D. HOELZER et. al.Basic information
Original name
Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL
Authors
GIEBEL, S. (616 Poland, guarantor), B. STELLA-HOLOWIECKA (616 Poland), M. KRAWCZYK-KULIS (616 Poland), N. GÖKBUGET (276 Germany), D. HOELZER (276 Germany), Michael DOUBEK (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), B. PIATKOWSKA-JAKUBAS (616 Poland), A.B. SKOTNICKI (616 Poland), H. DOMBRET (250 France), J.M. RIBERA (724 Spain), P.P. PICCALUGA (380 Italy), T. CZERW (616 Poland), S. KYRCZ-KRZEMIEN (616 Poland) and J. HOLOWIECKI (616 Poland)
Edition
Bone Marrow Transplantation, 2010, 0268-3369
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.660
RIV identification code
RIV/00216224:14110/10:00051241
Organization unit
Faculty of Medicine
UT WoS
000278573600021
Keywords in English
auto transplant; ALL; minimal residual disease
Tags
International impact
Změněno: 20/4/2012 11:05, Mgr. Michal Petr
Abstract
V originále
The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. Our results suggest the need to reevaluate the role of this treatment option in prospective trials.