| ŠERÝ, Omar, Radovan PŘIKRYL, Lukáš ČASTULÍK and František ŠŤASTNÝ. A118G polymorphism of OPRM1 gene is associated with schizophrenia. Journal of Molecular Neuroscience. USA: Springer New York, 2010, vol. 40, No 1, p. 1-8. ISSN 0895-8696. |
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@article{861954,
author = {Šerý, Omar and Přikryl, Radovan and Častulík, Lukáš and Šťastný, František},
article_location = {USA},
article_number = {1},
keywords = {schizophrenia association study polymorphism OPRM1 DNA},
language = {eng},
issn = {0895-8696},
journal = {Journal of Molecular Neuroscience},
title = {A118G polymorphism of OPRM1 gene is associated with schizophrenia},
volume = {40},
year = {2010}
}
TY - JOUR
ID - 861954
AU - Šerý, Omar - Přikryl, Radovan - Častulík, Lukáš - Šťastný, František
PY - 2010
TI - A118G polymorphism of OPRM1 gene is associated with schizophrenia
JF - Journal of Molecular Neuroscience
VL - 40
IS - 1
SP - 1-8
EP - 1-8
PB - Springer New York
SN - 08958696
KW - schizophrenia association study polymorphism OPRM1 DNA
N2 - Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in a groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups.
ER -
ŠERÝ, Omar, Radovan PŘIKRYL, Lukáš ČASTULÍK and František ŠŤASTNÝ. A118G polymorphism of OPRM1 gene is associated with schizophrenia. \textit{Journal of Molecular Neuroscience}. USA: Springer New York, 2010, vol.~40, No~1, p.~1-8. ISSN~0895-8696.
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