MARINI PALOMEQUE, María Victoria and Lumír KREJČÍ. Srs2: the Odd-Job Man in DNA repair. DNA Repair. ELSEVIER, 2010, vol. 9, No 3, 3 pp. ISSN 1568-7864. |
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Basic information | |
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Original name | Srs2: the Odd-Job Man in DNA repair |
Name in Czech | Srs2: Muž pro všechno v DNA opravě |
Authors | MARINI PALOMEQUE, María Victoria (858 Uruguay, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, guarantor, belonging to the institution). |
Edition | DNA Repair, ELSEVIER, 2010, 1568-7864. |
Other information | |
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Original language | English |
Type of outcome | Article in a journal |
Field of Study | 10600 1.6 Biological sciences |
Country of publisher | Netherlands |
Confidentiality degree | is not subject to a state or trade secret |
Impact factor | Impact factor: 4.293 |
RIV identification code | RIV/00216224:14310/10:00043104 |
Organization unit | Faculty of Science |
UT WoS | 000276016800008 |
Keywords in English | DNA repair; DNA damage; replication; genomic instability |
Tags | International impact, Reviewed |
Changed by | Changed by: doc. Mgr. Lumír Krejčí, Ph.D., učo 18098. Changed: 19/1/2011 05:36. |
Abstract |
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The genome is constantly threatened by various damaging agents and maintaining its integrity is crucial in all organisms. Several repair pathways have been implicated in the removal of different types of lesions from DNA. Among them, homologous recombination (HR) plays a key role in repair of double-strand breaks (DSBs). Although HR is a highly important repair mechanism, it has to be regulated to prevent it from interfering with other DNA repair pathways, generating toxic intermediates, or blocking the progression of the replication fork. Therefore, it is not surprising that cells have evolved mechanisms that counteract untimely HR events. In the yeast Saccharomyces cerevisiae, one of the pathways responsible for regulation of HR requires the action of the SRS2 gene product. Mutations in the SRS2 gene exhibit pleiotropic recombination phenotypes ranging from anti-recombinogenic in one aspect to pro-recombinogenic in another. In addition to its role in HR, Srs2 is also involved in other DNA metabolism processes, including post-replication repair (PRR), preservation of replication fork integrity, DNA-damage checkpoint responses, DNA triplet maintenance and non-homologous end joining (NHEJ). The aim of this review is to summarize the current knowledge about Srs2 and its effect on multiple DNA metabolic processes that generally affect genome stability. It would appear that Srs2 functions as an Odd-Job Man in these processes to make sure that the jobs proceed when and where they are needed. |
Abstract (in Czech) |
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The genome is constantly threatened by various damaging agents and maintaining its integrity is crucial in all organisms. Several repair pathways have been implicated in the removal of different types of lesions from DNA. Among them, homologous recombination (HR) plays a key role in repair of double-strand breaks (DSBs). Although HR is a highly important repair mechanism, it has to be regulated to prevent it from interfering with other DNA repair pathways, generating toxic intermediates, or blocking the progression of the replication fork. Therefore, it is not surprising that cells have evolved mechanisms that counteract untimely HR events. In the yeast Saccharomyces cerevisiae, one of the pathways responsible for regulation of HR requires the action of the SRS2 gene product. Mutations in the SRS2 gene exhibit pleiotropic recombination phenotypes ranging from anti-recombinogenic in one aspect to pro-recombinogenic in another. In addition to its role in HR, Srs2 is also involved in other DNA metabolism processes, including post-replication repair (PRR), preservation of replication fork integrity, DNA-damage checkpoint responses, DNA triplet maintenance and non-homologous end joining (NHEJ). The aim of this review is to summarize the current knowledge about Srs2 and its effect on multiple DNA metabolic processes that generally affect genome stability. It would appear that Srs2 functions as an Odd-Job Man in these processes to make sure that the jobs proceed when and where they are needed. |
Links | |
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GA301/09/1917, research and development project | Name: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu |
Investor: Czech Science Foundation | |
GD203/09/H046, research and development project | Name: Biochemie na rozcestí mezi in silico a in vitro |
Investor: Czech Science Foundation | |
LC06030, research and development project | Name: Biomolekulární centrum |
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre | |
ME10048, research and development project | Name: Vliv post-translačních modifikací na DNA opravu a rekombinaci. |
Investor: Ministry of Education, Youth and Sports of the CR, Research and Development Programme KONTAKT (ME) | |
MSM0021622413, plan (intention) | Name: Proteiny v metabolismu a při interakci organismů s prostředím |
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment |
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