| POUR, Luděk, Hana ŠVÁCHOVÁ, Zdeněk ADAM, Zuzana MIKULKOVÁ, Ivana BUREŠOVÁ, Lucie KOVÁŘOVÁ, Tomáš BÜCHLER, Miroslav PENKA, Jiří VORLÍČEK and Roman HÁJEK. Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma. Neoplasma. Bratislava: Slovenská akademie věd Bratislava, 2010, vol. 57, No 1, p. 29-34. ISSN 0028-2685. |
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@article{864694,
author = {Pour, Luděk and Šváchová, Hana and Adam, Zdeněk and Mikulková, Zuzana and Burešová, Ivana and Kovářová, Lucie and Büchler, Tomáš and Penka, Miroslav and Vorlíček, Jiří and Hájek, Roman},
article_location = {Bratislava},
article_number = {1},
keywords = {Angiogenesis; cytokines; high-dose chemotherapy; multiple myeloma; therapeutic response},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma.},
volume = {57},
year = {2010}
}
TY - JOUR
ID - 864694
AU - Pour, Luděk - Šváchová, Hana - Adam, Zdeněk - Mikulková, Zuzana - Burešová, Ivana - Kovářová, Lucie - Büchler, Tomáš - Penka, Miroslav - Vorlíček, Jiří - Hájek, Roman
PY - 2010
TI - Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma.
JF - Neoplasma
VL - 57
IS - 1
SP - 29-34
EP - 29-34
PB - Slovenská akademie věd Bratislava
SN - 00282685
KW - Angiogenesis
KW - cytokines
KW - high-dose chemotherapy
KW - multiple myeloma
KW - therapeutic response
N2 - Our aim was to establish whether the pretreatment levels of angiogenesis activators and inhibitors can be used to predict clinical responses to treatment that included high-dose chemotherapy with peripheral stem cell support. Patients with complete or very good partial response had higher TSP-1 levels in the bone marrow plasma than the partial or insufficient response subgroups. There were no correlations between the pretreatment levels of VEGF, bFGF, endostatin, or angiostatin and the treatment response. Pretreatment concentrations of HGF and TSP-1 were predictive factors for treatment response. Patients with low angiogenesis rate as determined by the relative HGF and TSP-1 concentrations were more likely to achieve complete or very good partial response after high-dose chemotherapy.
ER -
POUR, Luděk, Hana ŠVÁCHOVÁ, Zdeněk ADAM, Zuzana MIKULKOVÁ, Ivana BUREŠOVÁ, Lucie KOVÁŘOVÁ, Tomáš BÜCHLER, Miroslav PENKA, Jiří VORLÍČEK and Roman HÁJEK. Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma. \textit{Neoplasma}. Bratislava: Slovenská akademie věd Bratislava, 2010, vol.~57, No~1, p.~29-34. ISSN~0028-2685.
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