Detailed Information on Publication Record
2010
Bullous pemphigoid and internal diseases: A case-control study.
JEDLIČKOVÁ, Hana, Miloslav HLUBINKA, Tomáš PAVLÍK, Věra SEMRÁDOVÁ, Eva BUDINSKÁ et. al.Basic information
Original name
Bullous pemphigoid and internal diseases: A case-control study.
Authors
JEDLIČKOVÁ, Hana (203 Czech Republic, guarantor), Miloslav HLUBINKA (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic), Věra SEMRÁDOVÁ (203 Czech Republic), Eva BUDINSKÁ (703 Slovakia) and Zdeněk VLAŠÍN (203 Czech Republic)
Edition
European Journal of Dermatology, Francie, John Libbey Eurotext, 2010, 1167-1122
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
France
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.421
RIV identification code
RIV/00216224:14110/10:00043272
Organization unit
Faculty of Medicine
UT WoS
000274218000015
Keywords in English
bullous pemphigoid; cancer; diabetes mellitus; etiopathogenesis; neurological disorder
Tags
International impact, Reviewed
Změněno: 2/8/2010 11:17, RNDr. Tomáš Pavlík, Ph.D.
Abstract
V originále
To study associations of bullous pemphigoid (BP) with internal diseases, we conducted a retrospective case control study assessing the frequency of selected diseases: diabetes mellitus, neurological diseases, malignant tumors, benign prostate hyperplasia, hypertension and ischemic heart disease in patients with BP. 89 atients with BP, whose data were retrieved from the register of the Centre of bullous diseases from the period of 1991-2006, were matched with 89 controls of the same age and gender, recruited from patients treated for other skin diseases. The frequency of internal diseases at the time of the onset of BP was evaluated by unconditional logistic regression adjusted for age and gender and maximum likelihood test for contingency tables. Neurological disease was found in 42.7% of the patients and in 19.1% of controls. This difference was statistically significant (p value = 0.001). Moreover, regression analysis has shown that patients with neurological disease in the age group > 80 years have significantly higher risk of pemphigoid than patients without neurological disease (odds ratio 10.55; 95% confidence interval 2.68 to 41.49). Most frequent were cerebral stroke in men and dementia in women. For other diseases and other age groups, no statistically significant influence was found.