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@article{869481,
author = {Špinar, Jindřich and Vítovec, Jiří and Souček, Miroslav and Dušek, Ladislav and Pavlík, Tomáš and et, al.},
keywords = {Hypertension; Losartan; Ramipril; Cough},
language = {cze},
issn = {0167-5273},
journal = {International Journal of Cardiology},
title = {CORD: Comparison of Recommended Doses of ace inhibitors and angiotensin II receptor blockers},
year = {2009}
}
TY - JOUR
ID - 869481
AU - Špinar, Jindřich - Vítovec, Jiří - Souček, Miroslav - Dušek, Ladislav - Pavlík, Tomáš - et, al.
PY - 2009
TI - CORD: Comparison of Recommended Doses of ace inhibitors and angiotensin II receptor blockers
JF - International Journal of Cardiology
SN - 01675273
KW - Hypertension
KW - Losartan
KW - Ramipril
KW - Cough
N2 - The CORD trials tested ramipril and losartan in patients with hypertension. CORD A randomised 4016 patients with blood pressure (BP) < 160/100 mm Hg, who had been treated with an ACEI for > 3 months. The patients discontinued ACEI and switched to losartan. After 1 month the BP decreased to 7.7/4.7 mm Hg (p < 0.001) and after 1 year to 13.8/8.7 mm Hg (p < 0.001). CORD B compared ramipril and losartan in 3813 patients with hypertension who were not being treated with an ACEI or ARB. The patients were randomised to ramipril (n = 1926) or losartan (n = 1887). After 1 year the BP decreased in the ramipril group to 21.8/13.7 mm Hg (p < 0.001) and in the losartan group to 22.0/13.3 mm Hg (p < 0.001). No significant differences were found between the groups. No differences were in serious adverse events. Dry cough was more frequently after ramipril (33 vs 4, p < 0.001).
ER -
ŠPINAR, Jindřich, Jiří VÍTOVEC, Miroslav SOUČEK, Ladislav DUŠEK, Tomáš PAVLÍK a al. ET. CORD: Comparison of Recommended Doses of ace inhibitors and angiotensin II receptor blockers. \textit{International Journal of Cardiology}. 2009. ISSN~0167-5273.
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