Assocition of  the ACE gene I/D polymorphism and left
myocardial systolic dysfunction in patients with acute ST
elevations myocardial infarction treated by primary PCI

a 2009

Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří PAŘENICA, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK et. al.

Basic information

Original name

Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI

Authors

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří PAŘENICA, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Martin TESÁK, Jindřich ŠPINAR and Anna VAŠKŮ

Edition

Heart Failure 2009, 2009

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

Genetics and molecular biology

Country of publisher

France

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords (in Czech)

ACE, gen, polymorfismus, infarkt myokardu

Keywords in English

ACE, gene, polymorphism, myocardial infarction

Změněno: 1/2/2010 13:05, prof. RNDr. Monika Pávková Goldbergová, Ph.D.

Abstract

V originále

The ACE gene I/D polymorphism has been implicated in the development of MI, hypertension, and left ventricular hypertrophy. The goal of study was the exploration of the associations between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and post-myocardial infarction (MI) left ventricular systolic dysfunction. A total of 450 patients with acute MI with ST elevations treated by primary PCI (330 pts without heart failure - Killip I, 120 pts with acute heart failure in time of hospitalisation) and control group of 200 subjects were available for study. Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to median of ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA).

Links

NR9356, research and development project

Name: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Investor: Ministry of Health of the CR, Complex estimation of relation of MMP-1,2,3,9,TIMP-1 and ACE polymorphisms to left ventricuzlar remodelation and to medium-term prognosis after acute infarct myocardum with ST elevation treated by primary PCI

Citovat

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jiří PAŘENICA, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Martin TESÁK, Jindřich ŠPINAR and Anna VAŠKŮ. Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI. In Heart Failure 2009. 2009.

@proceedings{869974,
   author = {Pávková Goldbergová, Monika and Pařenica, Jiří and Kala, Petr and Poloczek, Martin and Maňousek, Jan and Tesák, Martin and Špinar, Jindřich and Vašků, Anna},
   booktitle = {Heart Failure 2009},
   keywords = {ACE, gene, polymorphism, myocardial infarction},
   language = {eng},
   title = {Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI},
   year = {2009}
}

TY  - CONF
ID  - 869974
AU  - Pávková Goldbergová, Monika - Pařenica, Jiří - Kala, Petr - Poloczek, Martin - Maňousek, Jan - Tesák, Martin - Špinar, Jindřich - Vašků, Anna
PY  - 2009
TI  - Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI
KW  - ACE, gene, polymorphism, myocardial infarction
N2  - The ACE gene I/D polymorphism has been implicated in the development of MI, hypertension, and left ventricular hypertrophy. The goal of study was the exploration of the associations between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and post-myocardial infarction (MI) left ventricular systolic dysfunction. A total of 450 patients with acute MI with ST elevations treated by primary PCI (330 pts without heart failure - Killip I, 120 pts with acute heart failure in time of hospitalisation) and control group of 200 subjects were available for study. Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to median of ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA).
ER  -

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