Matrix metalloproteinase-2 and oxidative stress in patients
with STEMI treated by primary PCI

a 2009

Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK et. al.

Základní údaje

Originální název

Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI

Autoři

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Zdena ČERMÁKOVÁ, Ondřej TOMAN, Daniela TOMČÍKOVÁ a Jindřich ŠPINAR

Vydání

ESC CONGRESS 2009, 2009

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

Genetika a molekulární biologie

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

UT WoS

000208702604134

Klíčová slova česky

MMP2, gen, polymorfismus

Klíčová slova anglicky

MMP2, gene, polymorphism, MI

Změněno: 1. 2. 2010 13:24, prof. RNDr. Monika Pávková Goldbergová, Ph.D.

Anotace

V originále

Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI.

Návaznosti

NR9356, projekt VaV

Název: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Investor: Ministerstvo zdravotnictví ČR, Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Citovat

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Zdena ČERMÁKOVÁ, Ondřej TOMAN, Daniela TOMČÍKOVÁ a Jindřich ŠPINAR. Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI. In ESC CONGRESS 2009. 2009.

@proceedings{869982,
   author = {Pařenica, Jiří and Pávková Goldbergová, Monika and Kala, Petr and Poloczek, Martin and Maňousek, Jan and Čermáková, Zdena and Toman, Ondřej and Tomčíková, Daniela and Špinar, Jindřich},
   booktitle = {ESC CONGRESS 2009},
   keywords = {MMP2, gene, polymorphism, MI},
   language = {eng},
   title = {Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI},
   year = {2009}
}

TY  - CONF
ID  - 869982
AU  - Pařenica, Jiří - Pávková Goldbergová, Monika - Kala, Petr - Poloczek, Martin - Maňousek, Jan - Čermáková, Zdena - Toman, Ondřej - Tomčíková, Daniela - Špinar, Jindřich
PY  - 2009
TI  - Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI
KW  - MMP2, gene, polymorphism, MI
N2  - Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI.
ER  -

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