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@proceedings{869982, author = {Pařenica, Jiří and Pávková Goldbergová, Monika and Kala, Petr and Poloczek, Martin and Maňousek, Jan and Čermáková, Zdena and Toman, Ondřej and Tomčíková, Daniela and Špinar, Jindřich}, booktitle = {ESC CONGRESS 2009}, keywords = {MMP2, gene, polymorphism, MI}, language = {eng}, title = {Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI}, year = {2009} }
TY - CONF ID - 869982 AU - Pařenica, Jiří - Pávková Goldbergová, Monika - Kala, Petr - Poloczek, Martin - Maňousek, Jan - Čermáková, Zdena - Toman, Ondřej - Tomčíková, Daniela - Špinar, Jindřich PY - 2009 TI - Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI KW - MMP2, gene, polymorphism, MI N2 - Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI. ER -
PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Zdena ČERMÁKOVÁ, Ondřej TOMAN, Daniela TOMČÍKOVÁ a Jindřich ŠPINAR. Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI. In \textit{ESC CONGRESS 2009}. 2009.
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