The association between TaqI A polymorphism of ANKK1 (DRD2)
gene and ADHD in the Czech boys aged between 6 and 13 years

J 2010

The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years

PACLT, Ivo, Ivana DRTÍLKOVÁ, Marta KOPEČKOVÁ, Pavel THEINER, Omar ŠERÝ et. al.

Základní údaje

Originální název

The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years

Název česky

Vztah mezi polymorfizmem TaqI A genu pro ANKK1 (DRD2) a ADHD u českých chlapců ve věku 6 až 13 let

Autoři

PACLT, Ivo (203 Česká republika, garant, domácí), Ivana DRTÍLKOVÁ (203 Česká republika, domácí), Marta KOPEČKOVÁ (203 Česká republika), Pavel THEINER (203 Česká republika, domácí), Omar ŠERÝ (203 Česká republika, domácí) a Naďa ČERMÁKOVÁ (203 Česká republika)

Vydání

Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2010, 0172-780X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Švédsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.621

Kód RIV

RIV/00216224:14310/10:00056952

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000288581900020

Klíčová slova česky

ANKK1 DRD2 ADHD hyperkinetická porucha

Klíčová slova anglicky

ADHD association DRD2

Štítky

AKb, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 4. 2012 02:13, Mgr. Michal Petr

Anotace

ORIG CZ

V originále

OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity. PatientS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719).

Česky

V rámci asociační studie jsme objevili velmi signifikantní statistický vztah mezi polymorfizmem genu pro DRD2 a ADHD u chlapců České republiky.

Návaznosti

NR9298, projekt VaV

Název: Rizikové faktory u perzistentní formy hyperkinetické poruchy(ADHD).Longitudinální,klinická a molekulárně-genetická studie.

Investor: Ministerstvo zdravotnictví ČR, Rizikové faktory u perzistentní formy hyperkinetické poruchy (ADHD). Longitudinální, klinická a molekulárně-genetická studie

Citovat

PACLT, Ivo, Ivana DRTÍLKOVÁ, Marta KOPEČKOVÁ, Pavel THEINER, Omar ŠERÝ a Naďa ČERMÁKOVÁ. The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2010, roč. 31, č. 1, s. 23-28. ISSN 0172-780X.

@article{873258,
   author = {Paclt, Ivo and Drtílková, Ivana and Kopečková, Marta and Theiner, Pavel and Šerý, Omar and Čermáková, Naďa},
   article_location = {Sweden, Stockholm},
   article_number = {1},
   keywords = {ADHD association DRD2},
   language = {eng},
   issn = {0172-780X},
   journal = {Neuroendocrinology Letters},
   title = {The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years},
   volume = {31},
   year = {2010}
}

TY  - JOUR
ID  - 873258
AU  - Paclt, Ivo - Drtílková, Ivana - Kopečková, Marta - Theiner, Pavel - Šerý, Omar - Čermáková, Naďa
PY  - 2010
TI  - The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years
JF  - Neuroendocrinology Letters
VL  - 31
IS  - 1
SP  - 23-28
EP  - 23-28
PB  - Maghira and Maas Publications
SN  - 0172780X
KW  - ADHD association DRD2
N2  - OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity. PatientS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719).
ER  -

PACLT, Ivo, Ivana DRTÍLKOVÁ, Marta KOPEČKOVÁ, Pavel THEINER, Omar ŠERÝ a Naďa ČERMÁKOVÁ. The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, 2010, roč.~31, č.~1, s.~23-28. ISSN~0172-780X.

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