| NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ a Miroslava SOUČEK. Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2009, roč. 1173, č. 25, s. 501-508, 7 s. ISSN 0077-8923. |
Další formáty:
BibTeX
LaTeX
RIS
@article{875827,
author = {Němec, Petr and PavkovaandGoldbergova, Monika and Gatterová, Jindra and Vašků, Anna and Souček, Miroslava},
article_location = {New York, USA},
article_number = {25},
keywords = {autoantibody; gene; interleukin-10; polymorphism; rheumatoid arthritis; severity},
language = {eng},
issn = {0077-8923},
journal = {Ann N Y Acad Sci},
title = {Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis},
volume = {1173},
year = {2009}
}
TY - JOUR
ID - 875827
AU - Němec, Petr - Pavkova-Goldbergova, Monika - Gatterová, Jindra - Vašků, Anna - Souček, Miroslava
PY - 2009
TI - Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis
JF - Ann N Y Acad Sci
VL - 1173
IS - 25
SP - 501-508
EP - 501-508
PB - New York Academy of Sciences
SN - 00778923
KW - autoantibody
KW - gene
KW - interleukin-10
KW - polymorphism
KW - rheumatoid arthritis
KW - severity
N2 - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
ER -
NĚMEC, Petr, Monika PAVKOVA-GOLDBERGOVA, Jindra GATTEROVÁ, Anna VAŠKŮ a Miroslava SOUČEK. Association of polymorfism in interleukin-10 gene promoter with antibody production in patients with rhematoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2009, roč.~1173, č.~25, s.~501-508, 7 s. ISSN~0077-8923.
|
