Cytokine response in severe sepsis: predicting and modeling the
course of illness

a 2010

Cytokine response in severe sepsis: predicting and modeling the course of illness

MALÁSKA, Jan, Milan KRATOCHVÍL, Michal KÝR, Petr JABANDŽIEV, Filip OTEVŘEL et. al.

Basic information

Original name

Cytokine response in severe sepsis: predicting and modeling the course of illness

Authors

MALÁSKA, Jan, Milan KRATOCHVÍL, Michal KÝR, Petr JABANDŽIEV, Filip OTEVŘEL, Katarína MURIOVÁ, Michal FEDORA, Vladimír ŠRÁMEK, Jaroslav MICHÁLEK and Pavel ŠEVČÍK

Edition

Critical Care 14, Suppl 1, P37, 2010

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

ISSN

DOI

http://dx.doi.org/10.1186/cc8269

Abstract

V originále

Severe sepsis remains one of the most threatening conditions in intensive care. During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. These biomarkers were successfully used as predictors in animal studies. Data from humans, especially comparison between children and adults, are limited. Hence, in this study we widely describe systemic cytokine response in this type of patient population. Methods Prospective study of 37 subjects (20 children, 17 adults) hospitalized with severe sepsis in intensive care. We measured CRP, procalcitonin, TNF, IL-1beta, IL-4, IL-6, IL-8, IL-10, IL-12, TREM-1. ANOVA models were specified using Proc Mixed. Study was fully approved by an ethics committee. Results We identified a correlation of CRP levels with mortality or presence of shock. We found a distinct feature of CRP in adults with pronounced dynamic dichotomy in these subjects. Levels of IL-6 were significantly different in adult patients in the context of shock states. High IL-6 levels in the beginning of sepsis were associated with shock during progression of illness. Highest risk of death was in adult patients associated with TREM-1 sustained high after 48 hours after sepsis onset. Otherwise, there was no correlation with death, shock states and SOFA score for PCT, TNF, IL-1beta, IL-4, IL-8, IL-10, and IL-12. Response of circulating factors in patients with severe sepsis is heterogeneous in the adult and children population and has some distinct features according to the dynamics of CRP, IL-6 and TREM-1.

Citovat

MALÁSKA, Jan, Milan KRATOCHVÍL, Michal KÝR, Petr JABANDŽIEV, Filip OTEVŘEL, Katarína MURIOVÁ, Michal FEDORA, Vladimír ŠRÁMEK, Jaroslav MICHÁLEK and Pavel ŠEVČÍK. Cytokine response in severe sepsis: predicting and modeling the course of illness. In Critical Care 14, Suppl 1, P37. 2010. ISSN 1364-8535. Available from: https://dx.doi.org/10.1186/cc8269.

@proceedings{876036,
   author = {Maláska, Jan and Kratochvíl, Milan and Kýr, Michal and Jabandžiev, Petr and Otevřel, Filip and Muriová, Katarína and Fedora, Michal and Šrámek, Vladimír and Michálek, Jaroslav and Ševčík, Pavel},
   booktitle = {Critical Care 14, Suppl 1, P37},
   doi = {http://dx.doi.org/10.1186/cc8269},
   language = {eng},
   title = {Cytokine response in severe sepsis: predicting and modeling the course of illness},
   year = {2010}
}

TY  - CONF
ID  - 876036
AU  - Maláska, Jan - Kratochvíl, Milan - Kýr, Michal - Jabandžiev, Petr - Otevřel, Filip - Muriová, Katarína - Fedora, Michal - Šrámek, Vladimír - Michálek, Jaroslav - Ševčík, Pavel
PY  - 2010
TI  - Cytokine response in severe sepsis: predicting and modeling the course of illness
N2  - Severe sepsis remains one of the most threatening conditions in intensive care. During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. These biomarkers were successfully used as predictors in animal studies. Data from humans, especially comparison between children and adults, are limited. Hence, in this study we widely describe systemic cytokine response in this type of patient population. Methods Prospective study of 37 subjects (20 children, 17 adults) hospitalized with severe sepsis in intensive care. We measured CRP, procalcitonin, TNF, IL-1beta, IL-4, IL-6, IL-8, IL-10, IL-12, TREM-1. ANOVA models were specified using Proc Mixed. Study was fully approved by an ethics committee. Results We identified a correlation of CRP levels with mortality or presence of shock. We found a distinct feature of CRP in adults with pronounced dynamic dichotomy in these subjects. Levels of IL-6 were significantly different in adult patients in the context of shock states. High IL-6 levels in the beginning of sepsis were associated with shock during progression of illness. Highest risk of death was in adult patients associated with TREM-1 sustained high after 48 hours after sepsis onset. Otherwise, there was no correlation with death, shock states and SOFA score for PCT, TNF, IL-1beta, IL-4, IL-8, IL-10, and IL-12. Response of circulating factors in patients with severe sepsis is heterogeneous in the adult and children population and has some distinct features according to the dynamics of CRP, IL-6 and TREM-1.
ER  -

MALÁSKA, Jan, Milan KRATOCHVÍL, Michal KÝR, Petr JABANDŽIEV, Filip OTEVŘEL, Katarína MURIOVÁ, Michal FEDORA, Vladimír ŠRÁMEK, Jaroslav MICHÁLEK and Pavel ŠEVČÍK. Cytokine response in severe sepsis: predicting and modeling the course of illness. In \textit{Critical Care 14, Suppl 1, P37}. 2010. ISSN~1364-8535. Available from: https://dx.doi.org/10.1186/cc8269.

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