Distinct Roles of TRAMP complexes in yeast RNA Metabolism

VAŇÁČOVÁ, Štěpánka. Distinct Roles of TRAMP complexes in yeast RNA Metabolism. In Messenger RNA 3' ends and gene expression - EMBO workshop. 2009.

Základní údaje

• Originální název: Distinct Roles of TRAMP complexes in yeast RNA Metabolism
• Název česky: Distinct Roles of TRAMP complexes in yeast RNA Metabolism
• Autoři: VAŇÁČOVÁ, Štěpánka.
• Vydání: Messenger RNA 3' ends and gene expression - EMBO workshop, 2009.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Konferenční abstrakt
• Obor: Genetika a molekulární biologie
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• WWW: URL
• Organizační jednotka: Přírodovědecká fakulta
• Klíčová slova anglicky: Messenger RNA 3 prime end formation provides a clear paradigm for such an interconnection point as it represents the cross-over between transcribing a gene and translating its messenger RNA.
• Příznaky: Mezinárodní význam

Anotace

The scientific programme for this Oxford EMBO workshop started with gene transcription, how the chromatin template is made ready for transcription and how the end of the gene is connected to its beginning. This transcription focus will then lead into how processing of the initial pre-mRNA is coupled to transcription, both splicing, but more importantly 3 end processing of: histone, polyA+ mRNAs, small stable RNAs (snRNA and snoRNA) and cryptic unstable RNAs (CUTs). Following nuclear export, mRNA translation is also intimately coupled to the appropriate structure of its 3 end, be this the polyA tail or a hairpin as in histone mRNA. The final critical stage in gene expression is the regulation of mRNA turn over, again closely connected to the integrity of the polyA tail. Superimposed on this whole process of gene expression is a surveillance process that acts at all stages.

Anotace česky

The scientific programme for this Oxford EMBO workshop started with gene transcription, how the chromatin template is made ready for transcription and how the end of the gene is connected to its beginning. This transcription focus will then lead into how processing of the initial pre-mRNA is coupled to transcription, both splicing, but more importantly 3 end processing of: histone, polyA+ mRNAs, small stable RNAs (snRNA and snoRNA) and cryptic unstable RNAs (CUTs). Following nuclear export, mRNA translation is also intimately coupled to the appropriate structure of its 3 end, be this the polyA tail or a hairpin as in histone mRNA. The final critical stage in gene expression is the regulation of mRNA turn over, again closely connected to the integrity of the polyA tail. Superimposed on this whole process of gene expression is a surveillance process that acts at all stages.