2009
Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins
HROŠŠOVÁ, Dominika, Stjepan ULDRIJAN, Aleš HAMPL, Zbyněk ZDRÁHAL, Štěpánka VAŇÁČOVÁ et. al.Základní údaje
Originální název
Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins
Název česky
Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins
Autoři
Vydání
RNA Club 2009, 2009
Další údaje
Jazyk
angličtina
Typ výsledku
Konferenční abstrakt
Obor
Genetika a molekulární biologie
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Organizační jednotka
Lékařská fakulta
ISSN
Klíčová slova česky
RNA Club
Klíčová slova anglicky
RNA Club
Příznaky
Mezinárodní význam
Změněno: 9. 4. 2010 10:57, prof. Mgr. Štěpánka Vaňáčová, Ph.D.
V originále
Modifications of 3' end of mRNAs plays important role in gene expression control. There are two groups of poly (A) polymerases (PAPs) present in the cell: canonical nuclear PAP, and non-canonical PAPs, that differ in the role they play in cell metabolism. There are 7 homologues of non-canonical PAPs in Homo sapiens. At the moment, they are rather poorly characterized. Recently, the largest homolog TUT4 (ZCCHC11) has been shown to play a role in gene expression regulation via the uridylation of specific miRNAs. Several other homologs, have also been shown to poses uridylation activity, in some cases along with the polyadenylation activity.
Česky
Modifications of 3' end of mRNAs plays important role in gene expression control. There are two groups of poly (A) polymerases (PAPs) present in the cell: canonical nuclear PAP, and non-canonical PAPs, that differ in the role they play in cell metabolism. There are 7 homologues of non-canonical PAPs in Homo sapiens. At the moment, they are rather poorly characterized. Recently, the largest homolog TUT4 (ZCCHC11) has been shown to play a role in gene expression regulation via the uridylation of specific miRNAs. Several other homologs, have also been shown to poses uridylation activity, in some cases along with the polyadenylation activity.
Návaznosti
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