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@article{879781, author = {Kilianová, Anna and Bébarová, Markéta and Beránková, Klára and Opatřilová, Radka and Pásek, Michal and Bartošová, Ladislava}, article_location = {Brno}, article_number = {1}, doi = {http://dx.doi.org/10.2754/avb201079010041}, keywords = {444; 44Bu; isomer; QRS-complex; sodium current; rat}, language = {eng}, issn = {0001-7213}, journal = {Acta Veterinaria Brno}, title = {Effect of Newly Synthesized Compounds 44Bu and 444 on QRS-Complex Width and Fast Sodium Current: Differences between Isomers}, volume = {79}, year = {2010} }
TY - JOUR ID - 879781 AU - Kilianová, Anna - Bébarová, Markéta - Beránková, Klára - Opatřilová, Radka - Pásek, Michal - Bartošová, Ladislava PY - 2010 TI - Effect of Newly Synthesized Compounds 44Bu and 444 on QRS-Complex Width and Fast Sodium Current: Differences between Isomers JF - Acta Veterinaria Brno VL - 79 IS - 1 SP - 41-49 EP - 41-49 SN - 00017213 KW - 444 KW - 44Bu KW - isomer KW - QRS-complex KW - sodium current KW - rat N2 - In this study, we explored the effect of both racemates and particular isomers of 44Bu and 444 on the QRS-complex width in vivo in rats and on INa in isolated rat ventricular myocytes. All variants of 44Bu and 444 (1.5 mg/kg) caused a significant QRS-widening reaching the peak effect at the 1st or 2nd min after their intravenous administration. 44Bu racemate widened the QRS-complex by 57%, significantly more than R- (33%-widening) and S-isomer (36%-widening). 444 racemate widened the QRS-complex by 64%, which was comparable to S-isomer (63%-widening), however, substantially more than R-isomer (40%-widening). Regarding the effect on INa, 44Bu caused a significantly deeper INa-block compared to 444 in the same concentration of 3.0 micromol/l (0.1 mg/kg). 44Bu racemate and R-isomer blocked INa similarly (91.7 and 91.8%-block, respectively), significantly more than S-isomer (82.4%-block). 444 R-isomer blocked INa less than racemate and S-isomer (by 31.7% vs. 48.3 and 50.2%, respectively). ER -
KILIANOVÁ, Anna, Markéta BÉBAROVÁ, Klára BERÁNKOVÁ, Radka OPATŘILOVÁ, Michal PÁSEK and Ladislava BARTOŠOVÁ. Effect of Newly Synthesized Compounds 44Bu and 444 on QRS-Complex Width and Fast Sodium Current: Differences between Isomers. \textit{Acta Veterinaria Brno}. Brno, 2010, vol.~79, No~1, p.~41-49. ISSN~0001-7213. Available from: https://dx.doi.org/10.2754/avb201079010041.
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