Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?

KŘEN, Leoš, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Martin SMRČKA, Ondřej SLABÝ, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ and Jaroslav MICHÁLEK. Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity? Journal of Neuroimmunology. Netherlands: Elsevier/North-Holland, 2010, vol. 220, 1-2, p. 131-135. ISSN 0165-5728. Available from: https://dx.doi.org/10.1016/j.jneuroim.2010.01.014.

Basic information

Original name

Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?

Name in Czech

Produkce neklasických imunomodulačních molekul HLA-G a HLA-E tumor infiltrujícími ameboidními mikrogliemi/makrofágy u glioblastomu: Role přirozené imunity?

Authors

KŘEN, Leoš (203 Czech Republic, guarantor, belonging to the institution), Katarína MÚČKOVÁ (703 Slovakia, belonging to the institution), Eva LŽIČAŘOVÁ (203 Czech Republic), Marek SOVA (203 Czech Republic), Václav VYBÍHAL (203 Czech Republic), Tomáš SVOBODA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Zdenka KŘENOVÁ (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic, belonging to the institution)

Edition

Journal of Neuroimmunology, Netherlands, Elsevier/North-Holland, 2010, 0165-5728

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.901

RIV identification code

RIV/00216224:14110/10:00051367

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jneuroim.2010.01.014

UT WoS

000276469900018

Keywords (in Czech)

HLA-E; HLA-G; Microglie; Glioblastom

Keywords in English

HLA-E; HLA-G; Microglia; Glioblastoma

Tags

International impact

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Abstract

V originále

The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of FILA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.

In Czech

Možná úloha neklasických imunomodulačních molekul HLA-G a HLA-E v protinádorové odpovědi a u glioblastomů není doposud dostatečně popsána. V této práci jsme se zaměřili na stanovení exprese těchto znaků aktivovanými tumor infiltrujícími mikrogliemi/makrofágy. Tato exprese byla zjištěna u většiny sledovaných glioblastomů. Pro vysvětlení podrobnějších mechanismů protinádorové imunity jsou nezbytné další studie.