www.rnaworkbench.com: A new program for analyzing RNA
interference

J 2008

www.rnaworkbench.com: A new program for analyzing RNA interference

SVOBODOVÁ VAŘEKOVÁ, Radka, Ivan BRADÁČ, Martin PLCHÚT, Michal ŠKRDLA, Michael WACENOVSKY et. al.

Základní údaje

Originální název

www.rnaworkbench.com: A new program for analyzing RNA interference

Autoři

SVOBODOVÁ VAŘEKOVÁ, Radka (203 Česká republika, garant, domácí), Ivan BRADÁČ (203 Česká republika), Martin PLCHÚT (203 Česká republika), Michal ŠKRDLA (203 Česká republika), Michael WACENOVSKY (40 Rakousko), Helmuth MAHR (40 Rakousko), Georg MAYER (40 Rakousko), Herbert TANNER (40 Rakousko), Hermann BRUGGER (40 Rakousko), Josef WITHALM (40 Rakousko), Peter LEDERER (40 Rakousko), Heinrich HUBER (40 Rakousko), Gerhard GIERLINGER (40 Rakousko), Ronald GRAF (40 Rakousko), Hakim TAFER (40 Rakousko), Ivo HOFACKER (40 Rakousko), Peter SCHUSTER (40 Rakousko) a Martin POLCIK (203 Česká republika)

Vydání

Computer Methods and Programs in Biomedicine, ELSEVIER, 2008, 0169-2607

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10403 Physical chemistry

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.220

Kód RIV

RIV/00216224:14310/08:00051393

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000254699500008

Klíčová slova anglicky

RNA interference; siRNA design; mRNA secondary structures; siRNA sequence rules

Štítky

Pb, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 3. 2012 03:54, doc. RNDr. Radka Svobodová, Ph.D.

Anotace

V originále

RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software.

Návaznosti

LC06030, projekt VaV

Název: Biomolekulární centrum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Biomolekulární centrum

Citovat

SVOBODOVÁ VAŘEKOVÁ, Radka, Ivan BRADÁČ, Martin PLCHÚT, Michal ŠKRDLA, Michael WACENOVSKY, Helmuth MAHR, Georg MAYER, Herbert TANNER, Hermann BRUGGER, Josef WITHALM, Peter LEDERER, Heinrich HUBER, Gerhard GIERLINGER, Ronald GRAF, Hakim TAFER, Ivo HOFACKER, Peter SCHUSTER a Martin POLCIK. www.rnaworkbench.com: A new program for analyzing RNA interference. Computer Methods and Programs in Biomedicine. ELSEVIER, 2008, roč. 90, č. 1, s. 89-94. ISSN 0169-2607.

@article{888527,
   author = {Svobodová Vařeková, Radka and Bradáč, Ivan and Plchút, Martin and Škrdla, Michal and Wacenovsky, Michael and Mahr, Helmuth and Mayer, Georg and Tanner, Herbert and Brugger, Hermann and Withalm, Josef and Lederer, Peter and Huber, Heinrich and Gierlinger, Gerhard and Graf, Ronald and Tafer, Hakim and Hofacker, Ivo and Schuster, Peter and Polcik, Martin},
   article_number = {1},
   keywords = {RNA interference; siRNA design; mRNA secondary structures; siRNA sequence rules},
   language = {eng},
   issn = {0169-2607},
   journal = {Computer Methods and Programs in Biomedicine},
   title = {www.rnaworkbench.com: A new program for analyzing RNA interference},
   volume = {90},
   year = {2008}
}

TY  - JOUR
ID  - 888527
AU  - Svobodová Vařeková, Radka - Bradáč, Ivan - Plchút, Martin - Škrdla, Michal - Wacenovsky, Michael - Mahr, Helmuth - Mayer, Georg - Tanner, Herbert - Brugger, Hermann - Withalm, Josef - Lederer, Peter - Huber, Heinrich - Gierlinger, Gerhard - Graf, Ronald - Tafer, Hakim - Hofacker, Ivo - Schuster, Peter - Polcik, Martin
PY  - 2008
TI  - www.rnaworkbench.com: A new program for analyzing RNA interference
JF  - Computer Methods and Programs in Biomedicine
VL  - 90
IS  - 1
SP  - 89-94
EP  - 89-94
PB  - ELSEVIER
SN  - 01692607
KW  - RNA interference
KW  - siRNA design
KW  - mRNA secondary structures
KW  - siRNA sequence rules
N2  - RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software.
ER  -

SVOBODOVÁ VAŘEKOVÁ, Radka, Ivan BRADÁČ, Martin PLCHÚT, Michal ŠKRDLA, Michael WACENOVSKY, Helmuth MAHR, Georg MAYER, Herbert TANNER, Hermann BRUGGER, Josef WITHALM, Peter LEDERER, Heinrich HUBER, Gerhard GIERLINGER, Ronald GRAF, Hakim TAFER, Ivo HOFACKER, Peter SCHUSTER a Martin POLCIK. www.rnaworkbench.com: A new program for analyzing RNA interference. \textit{Computer Methods and Programs in Biomedicine}. ELSEVIER, 2008, roč.~90, č.~1, s.~89-94. ISSN~0169-2607.

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