PILAŘOVÁ, Iveta, Sylvie HOLUBOVÁ, Marta FARKOVÁ, Přemysl LUBAL and Libuše TRNKOVÁ. Potenciometrická studie fyziologicky významných derivátů adeninu (Potentiometric study of physiologically important derivatives of adenine). In XXX. moderní elektrochemické metody - sborník přednášek. Ústí nad Labem: BEST Servis, Ústí nad Labem, 2010, 4 pp. ISBN 978-80-254-6710-7.
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Basic information
Original name Potenciometrická studie fyziologicky významných derivátů adeninu
Name (in English) Potentiometric study of physiologically important derivatives of adenine
Authors PILAŘOVÁ, Iveta (203 Czech Republic), Sylvie HOLUBOVÁ (203 Czech Republic), Marta FARKOVÁ (203 Czech Republic), Přemysl LUBAL (203 Czech Republic, guarantor) and Libuše TRNKOVÁ (203 Czech Republic).
Edition Ústí nad Labem, XXX. moderní elektrochemické metody - sborník přednášek, 4 pp. 2010.
Publisher BEST Servis, Ústí nad Labem
Other information
Original language Czech
Type of outcome Proceedings paper
Field of Study 10406 Analytical chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/10:00044256
Organization unit Faculty of Science
ISBN 978-80-254-6710-7
UT WoS 000283050900032
Keywords in English purine derivatives; potentiometry; protonation constant
Changed by Changed by: RNDr. Kamila Neplechová, Ph.D., učo 70207. Changed: 30/6/2010 12:57.
Abstract
V současné době jsou intenzívně studovány deriváty adeninu, rostlinné hormony cytokininy. Jejich deriváty olomoucin, roskovitin a bohemin působí jako inhibitory cyklin dependentních kináz a jsou perspektivními cytostatiky. Cílem této práce bylo studium protonizačních rovnováh adeninu, 6 benzylaminopurinu a jeho methoxy a chloroderivátů. Acidobazickou potenciometrickou titrací jsme stanovili rovnovážné protonizační konstanty a určili vliv teploty, intové síly, typu a polohy substituentu na pKa.
Abstract (in English)
There are currently intensively studied adenine derivatives known as cytokinins, which are plant hormones which promote plant growth, bud formation and branching stems. Important derivatives of cytokinins olomoucine, roscovitine, bohemine act as inhibitors of cyclin dependent kinases, thereby preventing cell division, and from this perspective, it appears as a potential cytostatics. The aim of this work was the thermodynamic study of protonisation of adenine, 6 benzylaminopurine and its methoxy and chlorine derivatives. Acid/base potentiometric titration allows to determine the equilibrium constants of protonisation pKa and determine the impact of substituent and its position on the benzyl. pKa dependence on temperature (15 to 37 C) and ionic strength (I = 0.1 M) are the basis for the thermodynamic evaluation of changes in enthalpy and entropy of the protonisation process. All the potentiometric determination of purine derivatives for reasons of solubility conducted in an environment of 10% (v/v) CH3OH in water.
Links
LC06035, research and development projectName: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.
Investor: Ministry of Education, Youth and Sports of the CR, Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
MSM0021622412, plan (intention)Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)
Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
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