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@article{892539,
author = {Skálová, Kateřina and Mollová, Klára and Michálek, Jaroslav},
article_location = {Netherlands},
article_number = {32},
keywords = {Dendritic cells; Cancer vaccine; Maturation cocktails},
language = {eng},
issn = {0264-410X},
journal = {Vaccine},
title = {Human myeloid dendritic cells for cancer therapy: does maturation matter?},
url = {http://dx.doi.org/10.1016/j.vaccine.2010.05.042},
volume = {28},
year = {2010}
}
TY - JOUR
ID - 892539
AU - Skálová, Kateřina - Mollová, Klára - Michálek, Jaroslav
PY - 2010
TI - Human myeloid dendritic cells for cancer therapy: does maturation matter?
JF - Vaccine
VL - 28
IS - 32
SP - 5153-5160
EP - 5153-5160
PB - Elsevier Science
SN - 0264410X
KW - Dendritic cells
KW - Cancer vaccine
KW - Maturation cocktails
UR - http://dx.doi.org/10.1016/j.vaccine.2010.05.042
N2 - Dendritic cells form the connection between innate and adoptive mechanisms of the immune system. As antigen-presenting cells, dendritic cells are capable of presenting tumour antigen and effectively stimulating immune response targeted against a tumour. A number of preclinical and clinical studies document dendritic cells' potential in anti-cancer treatment. Increasing knowledge of dendritic cell biology is leading to improved methods for their preparation for clinical application. Unfortunately, there is to date no consensus specifying optimal conditions for dendritic cell preparation in vitro. This review summarizes the methods used for preparing myeloid dendritic cells derived from monocytic precursors while focusing on cytokine cocktails used for their growth, maturation, and functional adjustment.
ER -
SKÁLOVÁ, Kateřina, Klára MOLLOVÁ a Jaroslav MICHÁLEK. Human myeloid dendritic cells for cancer therapy: does maturation matter? \textit{Vaccine}. Netherlands: Elsevier Science, 2010, roč.~28, č.~32, s.~5153-5160. ISSN~0264-410X.
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