Change in Referral Diagnoses and Diagnostic Delay in
Hypogammaglobulinaemic Patients during 28 Years in a Single
Referral Centre

J 2010

Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre

LITZMAN, Jiří, Dagmar ŠTIKAROVSKÁ, Zdenka PIKULOVÁ, Tomáš PAVLÍK, Sáva PEŠÁK et. al.

Základní údaje

Originální název

Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre

Autoři

LITZMAN, Jiří (203 Česká republika, garant, domácí), Dagmar ŠTIKAROVSKÁ (203 Česká republika), Zdenka PIKULOVÁ (203 Česká republika), Tomáš PAVLÍK (203 Česká republika, domácí), Sáva PEŠÁK (203 Česká republika, domácí), Vojtěch THON (203 Česká republika, domácí), Pavel KUKLÍNEK (203 Česká republika, domácí) a Jindřich LOKAJ (203 Česká republika, domácí)

Vydání

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, 1018-2438

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.235

Kód RIV

RIV/00216224:14110/10:00051417

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1159/000301584

UT WoS

000279595800012

Klíčová slova anglicky

Common variable immunodeficiency; X-linked agammaglobulinaemia; Immunoglobulins

Příznaky

Mezinárodní význam

Změněno: 20. 4. 2012 11:15, Mgr. Michal Petr

Anotace

V originále

Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Also, the median number of pneumonia episodes during the diagnostic delay decreased from 5 in the 1980s, to 1 in the 1990s and to 0 in the period of 2001-2008 (Spearmans correlation coefficient). While in the 1980s 17 of the 19 patients had pneumonia in their past history, in the period of 2001-2008 only 13 of the 33 patients were concerned. Conclusions: Our observation documents improved awareness of immunodeficiencies among physicians. It is supposed that earlier diagnosis will prevent complications, improve the quality of life and even survival of hypogammaglobulinaemic patients.

Citovat

LITZMAN, Jiří, Dagmar ŠTIKAROVSKÁ, Zdenka PIKULOVÁ, Tomáš PAVLÍK, Sáva PEŠÁK, Vojtěch THON, Pavel KUKLÍNEK a Jindřich LOKAJ. Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010, roč. 153, č. 1, s. 95-101. ISSN 1018-2438. Dostupné z: https://dx.doi.org/10.1159/000301584.

@article{892963,
   author = {Litzman, Jiří and Štikarovská, Dagmar and Pikulová, Zdenka and Pavlík, Tomáš and Pešák, Sáva and Thon, Vojtěch and Kuklínek, Pavel and Lokaj, Jindřich},
   article_number = {1},
   doi = {http://dx.doi.org/10.1159/000301584},
   keywords = {Common variable immunodeficiency; X-linked agammaglobulinaemia; Immunoglobulins},
   language = {eng},
   issn = {1018-2438},
   journal = {INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY},
   title = {Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre},
   volume = {153},
   year = {2010}
}

TY  - JOUR
ID  - 892963
AU  - Litzman, Jiří - Štikarovská, Dagmar - Pikulová, Zdenka - Pavlík, Tomáš - Pešák, Sáva - Thon, Vojtěch - Kuklínek, Pavel - Lokaj, Jindřich
PY  - 2010
TI  - Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre
JF  - INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
VL  - 153
IS  - 1
SP  - 95-101
EP  - 95-101
SN  - 10182438
KW  - Common variable immunodeficiency
KW  - X-linked agammaglobulinaemia
KW  - Immunoglobulins
N2  - Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Also, the median number of pneumonia episodes during the diagnostic delay decreased from 5 in the 1980s, to 1 in the 1990s and to 0 in the period of 2001-2008 (Spearmans correlation coefficient). While in the 1980s 17 of the 19 patients had pneumonia in their past history, in the period of 2001-2008 only 13 of the 33 patients were concerned. Conclusions: Our observation documents improved awareness of immunodeficiencies among physicians. It is supposed that earlier diagnosis will prevent complications, improve the quality of life and even survival of hypogammaglobulinaemic patients.
ER  -

LITZMAN, Jiří, Dagmar ŠTIKAROVSKÁ, Zdenka PIKULOVÁ, Tomáš PAVLÍK, Sáva PEŠÁK, Vojtěch THON, Pavel KUKLÍNEK a Jindřich LOKAJ. Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre. \textit{INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY}. 2010, roč.~153, č.~1, s.~95-101. ISSN~1018-2438. Dostupné z: https://dx.doi.org/10.1159/000301584.

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