Detailed Information on Publication Record
2010
Spectroscopic study of protonation of cytosine-containing oligonucleotides
HOLUBOVÁ, Sylvie, Přemysl LUBAL, Marta FARKOVÁ, Libuše TRNKOVÁ, Blanka HÉGROVÁ et. al.Basic information
Original name
Spectroscopic study of protonation of cytosine-containing oligonucleotides
Authors
HOLUBOVÁ, Sylvie (203 Czech Republic), Přemysl LUBAL (203 Czech Republic, guarantor), Marta FARKOVÁ (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic), Blanka HÉGROVÁ (203 Czech Republic) and Petra KRISTOVÁ (203 Czech Republic)
Edition
Pardubice, Sborníi 14. česko - slovenské spektroskopické konference, 100 pp. 2010
Publisher
Spektroskopická společnost Jana Marka Marci
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10406 Analytical chemistry
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/10:00044422
Organization unit
Faculty of Science
ISBN
978-80-7395-282-2
Keywords in English
spectroscopy; cytosine; protonation constant
Změněno: 2/8/2010 16:14, RNDr. Kamila Neplechová, Ph.D.
Abstract
V originále
Cytosine is an important building block of nucleic acids taking part in the process of genetic information transfer and transfer of energy of biologically important compounds by means of coenzymes. Due to acidobasic properties of bioligands, the presence of protonated species is dependent on the protonation constants. It was also shown that oligonucleotides (ODNs) concerning cytosine can form the so called structural i motif as a consequence of probable stabilization of the secondary structure of biomacromolecules. The aim of this work was to determine the protonation constants of ODNs varying the number of bases in order to see their influence on thermodynamic stability of studied ligands.
Links
LC06035, research and development project |
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MSM0021622412, plan (intention) |
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