Detailed Information on Publication Record
1999
Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes
MCGREGOR, Tracey, Zdeňka BALCAROVÁ, Yun QU, My-Chau TRAN, Renata ŽALUDOVÁ et. al.Basic information
Original name
Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes
Authors
MCGREGOR, Tracey (840 United States of America), Zdeňka BALCAROVÁ (203 Czech Republic), Yun QU (840 United States of America), My-Chau TRAN (840 United States of America), Renata ŽALUDOVÁ (203 Czech Republic), Viktor BRABEC (203 Czech Republic) and Nicholas FARRELL (840 United States of America, guarantor)
Edition
JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 0162-0134
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.463
Organization unit
Faculty of Science
Keywords in English
DNA; polynuclear platinum complexes
Změněno: 5/8/2010 13:37, RNDr. Kamila Neplechová, Ph.D.
Abstract
V originále
In this work, the B to Z transition of poly(dGdC).poly(dGdC) and the B to A transition of poly(dG).poly(dC) and of calf thymus (CT) DNA fragments modified by antitumor bifunctional polynuclear platinum complexes were investigated by circular dichroism (CD). The transition from the B to Z form of DNA was inducible with all three compounds studied, as indicated by an inversion of the B form spectra. The B to A transition in poly(dG) poly(dC) was induced easily by platinum complex binding alone, while the B to A transition in CT DNA was induced by ethanol but inhibited by coordination of all polynuclear platinum compounds used here. It was shown that the compound [(cisPtCl(NH3)(2))(2) mu(H2N(CH2)(6)NH2)] (NO3)(2) (1,1/c,c) was most effective at inhibiting the B to A transition in CT DNA, and [(transPtCl(NH3)(2))(,2 mu)(trans- Pt(NH3)(2)(H2N(CH2)(6)NH2)(2))](NO3)(4) (1,0,1/t,t,t) was least effective, while the effectiveness of [(transPtCl(NH3)(2))(,2) mu(H,2N(CH2)(6)NH2)] (NO3)(2) (1,1/t,t) fell between.
Links
GA305/99/0695, research and development project |
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