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@article{893190, author = {Žákovská, Alena and Nováková, Olga and Balcarová, Zdeňka and Bierbach, Uli and Farrell, Nicholas and Brabec, Viktor}, article_number = {3}, keywords = {DNA; platinum drug; quinoline; antitumor activity; conformation}, language = {eng}, issn = {0014-2956}, journal = {EUROPEAN JOURNAL OF BIOCHEMISTRY}, title = {DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]}, volume = {254}, year = {1998} }
TY - JOUR ID - 893190 AU - Žákovská, Alena - Nováková, Olga - Balcarová, Zdeňka - Bierbach, Uli - Farrell, Nicholas - Brabec, Viktor PY - 1998 TI - DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)] JF - EUROPEAN JOURNAL OF BIOCHEMISTRY VL - 254 IS - 3 SN - 00142956 KW - DNA KW - platinum drug KW - quinoline KW - antitumor activity KW - conformation N2 - Recent observations that several trans platinum complexes exhibit antitumor activity including activity in cisplatin-resistant tumor cells, violates the classical structure/activity relationships of platinum(II) complexes. According to these relationships, only bifunctional platinum(II) complexes with cis oriented leaving ligands should be therapeutically active. In order to contribute to the understanding of mechanisms underlying the antitumor activity of these new trans platinum analogs, various biochemical and biophysical methods as well as molecular modeling techniques were employed to study the modifications of DNA by antitumor trans[PtCl2(NH3)(quinoline)]. The results indicated that trans[PtCl2(NH3)(quinoline)] coordinated monofunctionally to DNA with a similar rate as transplatin. The overall rate of the rearrange ment to bifunctional adducts was also similar to that observed in the case of DNA modification by transplatin, i.e, it was relatively slow. ER -
ŽÁKOVSKÁ, Alena, Olga NOVÁKOVÁ, Zdeňka BALCAROVÁ, Uli BIERBACH, Nicholas FARRELL and Viktor BRABEC. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]. \textit{EUROPEAN JOURNAL OF BIOCHEMISTRY}. 1998, vol.~254, No~3, 11 pp. ISSN~0014-2956.
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