ŽÁKOVSKÁ, Alena, Olga NOVÁKOVÁ, Zdeňka BALCAROVÁ, Uli BIERBACH, Nicholas FARRELL and Viktor BRABEC. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1998, vol. 254, No 3, 11 pp. ISSN 0014-2956.
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Basic information
Original name DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]
Authors ŽÁKOVSKÁ, Alena (203 Czech Republic), Olga NOVÁKOVÁ (203 Czech Republic), Zdeňka BALCAROVÁ (203 Czech Republic), Uli BIERBACH (276 Germany), Nicholas FARRELL (840 United States of America) and Viktor BRABEC (203 Czech Republic, guarantor).
Edition EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 0014-2956.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Ukraine
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.249
Organization unit Faculty of Science
Keywords in English DNA; platinum drug; quinoline; antitumor activity; conformation
Changed by Changed by: RNDr. Kamila Neplechová, Ph.D., učo 70207. Changed: 5/8/2010 13:47.
Abstract
Recent observations that several trans platinum complexes exhibit antitumor activity including activity in cisplatin-resistant tumor cells, violates the classical structure/activity relationships of platinum(II) complexes. According to these relationships, only bifunctional platinum(II) complexes with cis oriented leaving ligands should be therapeutically active. In order to contribute to the understanding of mechanisms underlying the antitumor activity of these new trans platinum analogs, various biochemical and biophysical methods as well as molecular modeling techniques were employed to study the modifications of DNA by antitumor trans[PtCl2(NH3)(quinoline)]. The results indicated that trans[PtCl2(NH3)(quinoline)] coordinated monofunctionally to DNA with a similar rate as transplatin. The overall rate of the rearrange ment to bifunctional adducts was also similar to that observed in the case of DNA modification by transplatin, i.e, it was relatively slow.
Links
GA204/97/P028, research and development projectName: Biofyzikální analýza vlivu protinádorově účinných komplexů ruthenia na DNA
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