| BALCAROVÁ, Zdeňka, Jana KAŠPÁRKOVÁ, Alena ŽÁKOVSKÁ, Olga NOVÁKOVÁ, Maria F. SIVO, Giovanni NATILE and Viktor BRABEC. DNA interactions of a novel platinum drug, cis-[PtCl(NH3)(2)(N7-acyclovir)]. MOLECULAR PHARMACOLOGY. 1998, vol. 53, No 5, 10 pp. ISSN 0026-895X. |
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@article{893200,
author = {Balcarová, Zdeňka and Kašpárková, Jana and Žákovská, Alena and Nováková, Olga and Sivo, Maria F. and Natile, Giovanni and Brabec, Viktor},
article_number = {5},
keywords = {INTERSTRAND CROSS-LINKS; ANTITUMOR AGENTS; CELL-DEATH; COMPLEXES; CIS-DIAMMINEDICHLOROPLATINUM(II); ADDUCTS; FLUORESCENCE; CISPLATIN; TRANS-DIAMMINEDICHLOROPLATINUM(II); APOPTOSIS},
language = {eng},
issn = {0026-895X},
journal = {MOLECULAR PHARMACOLOGY},
title = {DNA interactions of a novel platinum drug, cis-[PtCl(NH3)(2)(N7-acyclovir)]},
volume = {53},
year = {1998}
}
TY - JOUR
ID - 893200
AU - Balcarová, Zdeňka - Kašpárková, Jana - Žákovská, Alena - Nováková, Olga - Sivo, Maria F. - Natile, Giovanni - Brabec, Viktor
PY - 1998
TI - DNA interactions of a novel platinum drug, cis-[PtCl(NH3)(2)(N7-acyclovir)]
JF - MOLECULAR PHARMACOLOGY
VL - 53
IS - 5
SN - 0026895X
KW - INTERSTRAND CROSS-LINKS
KW - ANTITUMOR AGENTS
KW - CELL-DEATH
KW - COMPLEXES
KW - CIS-DIAMMINEDICHLOROPLATINUM(II)
KW - ADDUCTS
KW - FLUORESCENCE
KW - CISPLATIN
KW - TRANS-DIAMMINEDICHLOROPLATINUM(II)
KW - APOPTOSIS
N2 - We synthesized a novel platinum drug, cis-[PtCl(NH3)(2)(N7-ACV)](+), in which ACV is the antiviral drug acyclovir [a deoxyriboguanosine analogue, 9-(2-hydroxyethoxymethyl)guanine]. This new compound exhibits antiviral efficacy in vitro and exhibits an antitumor activity profile different from that of cisplatin. To contribute to understanding the mechanisms underlying biological activity of this new compound, we studied modifications of natural and synthetic DNAs in cell-free media by cis-[PtCl(NH3)(2)(N7-ACV)](+) by various biochemical and biophysical methods.
ER -
BALCAROVÁ, Zdeňka, Jana KAŠPÁRKOVÁ, Alena ŽÁKOVSKÁ, Olga NOVÁKOVÁ, Maria F. SIVO, Giovanni NATILE and Viktor BRABEC. DNA interactions of a novel platinum drug, cis-[PtCl(NH3)(2)(N7-acyclovir)]. \textit{MOLECULAR PHARMACOLOGY}. 1998, vol.~53, No~5, 10 pp. ISSN~0026-895X.
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