Detailed Information on Publication Record
1997
DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]
ŽALUDOVÁ, Renata, Alena ŽÁKOVSKÁ, Jana KAŠPÁRKOVÁ, Zdeňka BALCAROVÁ, Oldřich VRÁNA et. al.Basic information
Original name
DNA modifications by antitumor trans-[PtCl2(E-iminoether)(2)]
Authors
ŽALUDOVÁ, Renata (203 Czech Republic), Alena ŽÁKOVSKÁ (203 Czech Republic), Jana KAŠPÁRKOVÁ (203 Czech Republic), Zdeňka BALCAROVÁ (203 Czech Republic), Oldřich VRÁNA (203 Czech Republic), Mauro COLUCCIA (380 Italy), Giovanni NATILE (380 Italy) and Viktor BRABEC (203 Czech Republic, guarantor)
Edition
MOLECULAR PHARMACOLOGY, 1997, 0026-895X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 4.921
Organization unit
Faculty of Science
Keywords in English
INTERSTRAND CROSS-LINKS; ANTI-TUMOR ACTIVITY; PLATINUM COMPLEXES; IN-VITRO; CISPLATIN; BINDING; CIS-DIAMMINEDICHLOROPLATINUM(II); ADDUCTS; CYTOTOXICITY; ANTIBODIES
Změněno: 5/8/2010 14:14, RNDr. Kamila Neplechová, Ph.D.
Abstract
V originále
Recent findings that an analogue of clinically ineffective transplatin, trans-[PtCl2(E-iminoether)(2)], exhibits antitumor activity has helped reevaluation of the empirical structure-antitumor activity relationship generally accepted for platinum(II) complexes. According to this relationship, only the cis geometry of leaving ligands in the bifunctional platinum(II) complexes, should be therapeutically active. Global modifications of natural DNAs in cell-free media by trans-[PtCl2(E-iminoether)(2)] were studied through various molecular biophysical methods and compared with modifications by cis-[PtCl2(E-iminoether)(2)], transplatin, cisplatin, and monofunctional chlorodiethylenetriamineplatinum(II) chloride.
Links
| GA204/97/P028, research and development project |
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