| BERÁNEK, Michal, Kateřina KAŇKOVÁ, Svatava TSCHÖPLOVÁ, Petr KOLÁŘ and Jiří VÁCHA. Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus. Current Eye Research. The Netherlands: Swets & Zeitlinger, 2003, 27/2003, No 2, p. 91-93. ISSN 0271-3683. |
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@article{894367,
author = {Beránek, Michal and Kaňková, Kateřina and Tschöplová, Svatava and Kolář, Petr and Vácha, Jiří},
article_location = {The Netherlands},
article_number = {2},
keywords = {extracellular matrix; genetic polymorphism; T2DM; proliferative retinopathy; TIMP},
language = {eng},
issn = {0271-3683},
journal = {Current Eye Research},
title = {Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus},
volume = {27/2003},
year = {2003}
}
TY - JOUR
ID - 894367
AU - Beránek, Michal - Kaňková, Kateřina - Tschöplová, Svatava - Kolář, Petr - Vácha, Jiří
PY - 2003
TI - Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus
JF - Current Eye Research
VL - 27/2003
IS - 2
SP - 91-93
EP - 91-93
PB - Swets & Zeitlinger
SN - 02713683
KW - extracellular matrix
KW - genetic polymorphism
KW - T2DM
KW - proliferative retinopathy
KW - TIMP
N2 - Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms (-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjects. Conclusions: Polymorphisms in the promoter region of the TIMP-3 gene were not associated with the PDR in the Caucasian T2DM patients.
ER -
BERÁNEK, Michal, Kateřina KAŇKOVÁ, Svatava TSCHÖPLOVÁ, Petr KOLÁŘ and Jiří VÁCHA. Three novel polymorphisms in the promoter region of the TIMP 3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus. \textit{Current Eye Research}. The Netherlands: Swets \&{} Zeitlinger, 2003, 27/2003, No~2, p.~91-93. ISSN~0271-3683.
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