Association of FcRn expression with lung abnormalities and IVIG
catabolism in patients with common variable immunodeficiency

J 2010

Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

FREIBERGER, Tomáš, Lucie GRODECKÁ, Barbora RAVČUKOVÁ, Barbora KUŘECOVÁ, Věra POSTRÁNECKÁ et. al.

Basic information

Original name

Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

Authors

FREIBERGER, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Lucie GRODECKÁ (203 Czech Republic, belonging to the institution), Barbora RAVČUKOVÁ (203 Czech Republic), Barbora KUŘECOVÁ (203 Czech Republic), Věra POSTRÁNECKÁ (203 Czech Republic), Jiří VLČEK (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Vojtěch THON (203 Czech Republic, belonging to the institution) and Jiří LITZMAN (203 Czech Republic, belonging to the institution)

Edition

CLINICAL IMMUNOLOGY, Elsevier, 2010, 1521-6616

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.932

RIV identification code

RIV/00216224:14110/10:00051454

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.clim.2010.05.006

UT WoS

000280907000011

Keywords in English

Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG

Abstract

V originále

Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications. Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG.Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.

Citovat

FREIBERGER, Tomáš, Lucie GRODECKÁ, Barbora RAVČUKOVÁ, Barbora KUŘECOVÁ, Věra POSTRÁNECKÁ, Jiří VLČEK, Jiří JARKOVSKÝ, Vojtěch THON and Jiří LITZMAN. Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency. CLINICAL IMMUNOLOGY. Elsevier, 2010, vol. 136, No 3, p. 419-425. ISSN 1521-6616. Available from: https://dx.doi.org/10.1016/j.clim.2010.05.006.

@article{897947,
   author = {Freiberger, Tomáš and Grodecká, Lucie and Ravčuková, Barbora and Kuřecová, Barbora and Postránecká, Věra and Vlček, Jiří and Jarkovský, Jiří and Thon, Vojtěch and Litzman, Jiří},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.clim.2010.05.006},
   keywords = {Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG},
   language = {eng},
   issn = {1521-6616},
   journal = {CLINICAL IMMUNOLOGY},
   title = {Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency},
   volume = {136},
   year = {2010}
}

TY  - JOUR
ID  - 897947
AU  - Freiberger, Tomáš - Grodecká, Lucie - Ravčuková, Barbora - Kuřecová, Barbora - Postránecká, Věra - Vlček, Jiří - Jarkovský, Jiří - Thon, Vojtěch - Litzman, Jiří
PY  - 2010
TI  - Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency
JF  - CLINICAL IMMUNOLOGY
VL  - 136
IS  - 3
SP  - 419-425
EP  - 419-425
PB  - Elsevier
SN  - 15216616
KW  - Neonatal Fc receptor
KW  - FcRn
KW  - Common variable immunodeficiency
KW  - Lung disease
KW  - IVIG
N2  - Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications. Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG.Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.
ER  -

FREIBERGER, Tomáš, Lucie GRODECKÁ, Barbora RAVČUKOVÁ, Barbora KUŘECOVÁ, Věra POSTRÁNECKÁ, Jiří VLČEK, Jiří JARKOVSKÝ, Vojtěch THON and Jiří LITZMAN. Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency. \textit{CLINICAL IMMUNOLOGY}. Elsevier, 2010, vol.~136, No~3, p.~419-425. ISSN~1521-6616. Available from: https://dx.doi.org/10.1016/j.clim.2010.05.006.

Detailed Information on Publication Record