| NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ a Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2010, roč. 1173, Sept, 8 s. ISSN 0077-8923. |
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@article{900500,
author = {Němec, Petr and Goldbergova, MP and Gatterova, Jiřina and Vašků, Anna and Souček, Miroslav},
article_location = {New York, USA},
article_number = {Sept},
keywords = {gene; RA; promoter; IL10; polymorphism},
language = {eng},
issn = {0077-8923},
journal = {Ann N Y Acad Sci},
title = {Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.},
volume = {1173},
year = {2010}
}
TY - JOUR
ID - 900500
AU - Němec, Petr - Goldbergova, MP - Gatterova, Jiřina - Vašků, Anna - Souček, Miroslav
PY - 2010
TI - Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.
JF - Ann N Y Acad Sci
VL - 1173
IS - Sept
PB - New York Academy of Sciences
SN - 00778923
KW - gene
KW - RA
KW - promoter
KW - IL10
KW - polymorphism
N2 - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
ER -
NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ a Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2010, roč.~1173, Sept, 8 s. ISSN~0077-8923.
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