Association of polymorphisms in interleukin-10 gene promoter
with autoantibody production in patients with rheumatoid
arthritis.

J 2010

Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ, Miroslav SOUČEK et. al.

Základní údaje

Originální název

Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

Autoři

NĚMEC, Petr (203 Česká republika, garant, domácí), MP GOLDBERGOVA (203 Česká republika, domácí), Jiřina GATTEROVA (203 Česká republika), Anna VAŠKŮ (203 Česká republika, domácí) a Miroslav SOUČEK (203 Česká republika, domácí)

Vydání

Ann N Y Acad Sci, New York, USA, New York Academy of Sciences, 2010, 0077-8923

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.847

Kód RIV

RIV/00216224:14110/10:00040797

Organizační jednotka

Lékařská fakulta

UT WoS

000270762800070

Klíčová slova anglicky

gene; RA; promoter; IL10; polymorphism

Změněno: 19. 1. 2011 15:21, prof. MUDr. Miroslav Souček, CSc.

Anotace

V originále

Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.

Návaznosti

NR7812, projekt VaV

Název: Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artritidy

Investor: Ministerstvo zdravotnictví ČR, Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artridity

Citovat

NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ a Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2010, roč. 1173, Sept, 8 s. ISSN 0077-8923.

@article{900500,
   author = {Němec, Petr and Goldbergova, MP and Gatterova, Jiřina and Vašků, Anna and Souček, Miroslav},
   article_location = {New York, USA},
   article_number = {Sept},
   keywords = {gene; RA; promoter; IL10; polymorphism},
   language = {eng},
   issn = {0077-8923},
   journal = {Ann N Y Acad Sci},
   title = {Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.},
   volume = {1173},
   year = {2010}
}

TY  - JOUR
ID  - 900500
AU  - Němec, Petr - Goldbergova, MP - Gatterova, Jiřina - Vašků, Anna - Souček, Miroslav
PY  - 2010
TI  - Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.
JF  - Ann N Y Acad Sci
VL  - 1173
IS  - Sept
PB  - New York Academy of Sciences
SN  - 00778923
KW  - gene
KW  - RA
KW  - promoter
KW  - IL10
KW  - polymorphism
N2  - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
ER  -

NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ a Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2010, roč.~1173, Sept, 8 s. ISSN~0077-8923.

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