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@proceedings{900999,
author = {Skálová, Kateřina and Mollová, Klára and Burešová, Ivana and Michálek, Jaroslav},
booktitle = {11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science},
keywords = {dendritic cells; maturation},
language = {eng},
title = {Comparison of five currently used DC maturation strategies and their influence on DC characteristics},
year = {2010}
}
TY - CONF
ID - 900999
AU - Skálová, Kateřina - Mollová, Klára - Burešová, Ivana - Michálek, Jaroslav
PY - 2010
TI - Comparison of five currently used DC maturation strategies and their influence on DC characteristics
KW - dendritic cells
KW - maturation
N2 - As antigen-presenting cells, dendritic cells (DC) are able to present tumor antigens and effectively stimulate both helper and cytotoxic T-cell response targeted against a tumor. That makes them a suitable source for in vitro cancer vaccines production. Increasing knowledge of DC biology leads to improved methods of their in vitro preparation, but there is to date no consensus specifying optimal conditions for that. It has been demonstrated that DCs derived from monocytic precursors matured in different conditions differ in their characteristics and functional adjustment. We compared five previously described cytokine combinations, currently used for DC maturation, and their effect on following DC characteristics: morphology, surface markers, cytokine production profiles, migratory capacity, capability of T-cell activation and cytotoxicity induction.
ER -
SKÁLOVÁ, Kateřina, Klára MOLLOVÁ, Ivana BUREŠOVÁ a Jaroslav MICHÁLEK. Comparison of five currently used DC maturation strategies and their influence on DC characteristics. In \textit{11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science}. 2010.
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