2010
STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
PAZDERA, PavelZákladní údaje
Originální název
STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
Název česky
STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
Autoři
PAZDERA, Pavel
Vydání
1. vyd. Vienna, Austria, XXIVth EUROPEAN COLLOQUIUM on HETEROCYCLIC CHEMISTRY, od s. 72-73, 2 s. 2010
Nakladatel
Book-of-Abstracts.com
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
10401 Organic chemistry
Stát vydavatele
Rakousko
Utajení
není předmětem státního či obchodního tajemství
Kód RIV
RIV/00216224:14310/10:00040195
Organizační jednotka
Přírodovědecká fakulta
ISBN
978-3-9502992-0-5
Klíčová slova česky
CATION-EXCHANGER RESINS ;PIPERAZINE; MONO-ACYLATION
Klíčová slova anglicky
CATION-EXCHANGER RESINS ;PIPERAZINE; MONO-ACYLATION
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 22. 4. 2011 11:02, doc. RNDr. Pavel Pazdera, CSc.
V originále
Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylation of piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the ground of facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study both types of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.
Česky
Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylation of piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the ground of facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study both types of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.
Návaznosti
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