2010
STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
PAZDERA, PavelZákladní údaje
Originální název
STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
Název česky
STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
Autoři
PAZDERA, Pavel
Vydání
1. vyd. Vienna, Austria, XXIVth EUROPEAN COLLOQUIUM on HETEROCYCLIC CHEMISTRY, od s. 72-73, 2 s. 2010
Nakladatel
Book-of-Abstracts.com
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
10401 Organic chemistry
Stát vydavatele
Rakousko
Utajení
není předmětem státního či obchodního tajemství
Označené pro přenos do RIV
Ano
Kód RIV
RIV/00216224:14310/10:00040195
Organizační jednotka
Přírodovědecká fakulta
ISBN
978-3-9502992-0-5
Klíčová slova česky
CATION-EXCHANGER RESINS ;PIPERAZINE; MONO-ACYLATION
Klíčová slova anglicky
CATION-EXCHANGER RESINS ;PIPERAZINE; MONO-ACYLATION
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 22. 4. 2011 11:02, doc. RNDr. Pavel Pazdera, CSc.
V originále
Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylation of piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the ground of facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study both types of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.
Česky
Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylation of piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the ground of facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study both types of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.
Návaznosti
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