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@inproceedings{901104,
author = {Pazdera, Pavel},
address = {Vienna, Austria},
booktitle = {XXIVth EUROPEAN COLLOQUIUM on HETEROCYCLIC CHEMISTRY},
edition = {1},
keywords = {CATION-EXCHANGER RESINS ;PIPERAZINE; MONO-ACYLATION},
language = {eng},
location = {Vienna, Austria},
isbn = {978-3-9502992-0-5},
pages = {72-73},
publisher = {Book-of-Abstracts.com},
title = {STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE},
year = {2010}
}
TY - JOUR
ID - 901104
AU - Pazdera, Pavel
PY - 2010
TI - STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE
PB - Book-of-Abstracts.com
CY - Vienna, Austria
SN - 9783950299205
KW - CATION-EXCHANGER RESINS ;PIPERAZINE
KW - MONO-ACYLATION
N2 - Direct N-monoacylation of piperazine was already described for its reaction with acyl chlorides or alkyl chlorocarbonates in acidified water (pH ca 3) with very bad yields - about 30 % of monoacyl piperazine. On the other hand, direct N-mono-benzylation of piperazine in the piperazinium chloride form by benzyl chloride in ethanol provides mono-product in excellent yield. N-monoacyl piperazines can be key building block in industrial piperazine chemistry, better than N-monobenzyl piperazine on the ground of facile deacylation. Possibilities for an application of cation-exchanger resins for better than described direct N-monoacylation reactions on piperazine by an action of different acylating agents in polar organic solvents were studied. For study both types of resins, i. e. strong acid (sulfonated polystyrene-divinylbenzene copolymer) and weak acid (acrylic acid-divinylbenzene copolymer) as cation-exchanger resins were used.
ER -
PAZDERA, Pavel. STUDY OF APPLICATIONS OF CATION-EXCHANGER RESINS FOR DIRECT N-MONOACYLATION ON PIPERAZINE. In \textit{XXIVth EUROPEAN COLLOQUIUM on HETEROCYCLIC CHEMISTRY}. 1. vyd. Vienna, Austria: Book-of-Abstracts.com, 2010, s.~72-73. ISBN~978-3-9502992-0-5.
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