| BOUCHAL, Pavel, Monika MUDROCHOVÁ, Zbyněk BORTLÍČEK, Theodoros ROUMELIOTIS, Eva BUDINSKÁ, Dominika VÁŇOVÁ, Lenka HERNYCHOVÁ, Iva STRUHÁROVÁ, Roman HRSTKA, Petr MÜLLER, Alexander SCHERL, Spiros D. GARBIS, Rudolf NENUTIL and Bořivoj VOJTĚŠEK. Biomarker discovery in low-grade breast cancer: An integrated, proteomics-based approach. In Abstract book of "3rd joint meeting on the role of p53, MDM2, AGR2/3 and ubiquitin/chaperone system in tumour biology". 2010. ISBN 978-80-86793-16-0. |
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@proceedings{902367,
author = {Bouchal, Pavel and Mudrochová, Monika and Bortlíček, Zbyněk and Roumeliotis, Theodoros and Budinská, Eva and Váňová, Dominika and Hernychová, Lenka and Struhárová, Iva and Hrstka, Roman and Müller, Petr and Scherl, Alexander and Garbis, Spiros D. and Nenutil, Rudolf and Vojtěšek, Bořivoj},
booktitle = {Abstract book of "3rd joint meeting on the role of p53, MDM2, AGR2/3 and ubiquitin/chaperone system in tumour biology"},
keywords = {breast cancer; metastasis; proteomics},
language = {eng},
isbn = {978-80-86793-16-0},
title = {Biomarker discovery in low-grade breast cancer: An integrated, proteomics-based approach},
year = {2010}
}
TY - CONF
ID - 902367
AU - Bouchal, Pavel - Mudrochová, Monika - Bortlíček, Zbyněk - Roumeliotis, Theodoros - Budinská, Eva - Váňová, Dominika - Hernychová, Lenka - Struhárová, Iva - Hrstka, Roman - Müller, Petr - Scherl, Alexander - Garbis, Spiros D. - Nenutil, Rudolf - Vojtěšek, Bořivoj
PY - 2010
TI - Biomarker discovery in low-grade breast cancer: An integrated, proteomics-based approach
SN - 9788086793160
KW - breast cancer
KW - metastasis
KW - proteomics
N2 - Breast cancer is the most common women cancer in the world. Traditional prognostic markers are, however, not sufficient for precise risk-group discrimination. Our effort has been focused on biomarker discovery in the set of 96 breast cancer primary tumors divided into several groups according to grade, lymph node and hormonal receptor status. Three proteomics approaches were involved in complex protein analysis of tissue lysates: SELDI-TOF MS, iTRAQ-2DLC-MS/MS and 2-D SDS-PAGE. Generally, our results indicate the following differences between the two studied groups: Differential expression of (i) cytoskeletal proteins, (ii) AGR family members and (iii) proteins involved in heme biosynthesis. These findings provide a solid data for further verification, functional studies and validation geared toward the establishment of novel biomarkers of metastatic processes in breast cancer.
ER -
BOUCHAL, Pavel, Monika MUDROCHOVÁ, Zbyněk BORTLÍČEK, Theodoros ROUMELIOTIS, Eva BUDINSKÁ, Dominika VÁŇOVÁ, Lenka HERNYCHOVÁ, Iva STRUHÁROVÁ, Roman HRSTKA, Petr MÜLLER, Alexander SCHERL, Spiros D. GARBIS, Rudolf NENUTIL and Bořivoj VOJTĚŠEK. Biomarker discovery in low-grade breast cancer: An integrated, proteomics-based approach. In \textit{Abstract book of ''3rd joint meeting on the role of p53, MDM2, AGR2/3 and ubiquitin/chaperone system in tumour biology''}. 2010. ISBN~978-80-86793-16-0.
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