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@proceedings{904164, author = {Jelínek, Jiří and Adkins, Irena and Šebo, P. and Michálek, Jaroslav}, booktitle = {1st International Conference on Advances in Cell and Gene Therapy and Immunotherapy: from basic research to clinical applications and 3rd Workshop on Immunotherapy.}, keywords = {T cells; CyaA toxoid; immunotherapy}, language = {eng}, isbn = {978-80-7392-137-8}, title = {In vitro activation of CMV-specific human CD8+ T cells by CyaA toxoids delivering pp65 epitopes}, year = {2010} }
TY - CONF ID - 904164 AU - Jelínek, Jiří - Adkins, Irena - Šebo, P. - Michálek, Jaroslav PY - 2010 TI - In vitro activation of CMV-specific human CD8+ T cells by CyaA toxoids delivering pp65 epitopes SN - 9788073921378 KW - T cells KW - CyaA toxoid KW - immunotherapy N2 - In this study, we investigated the capacity of two CyaA constructs to deliver epitopes from the CMV phosphoprotein pp65 to activate T cells of CMV-seropositive and CMV-seronegative healthy donors in vitro. Immune response of T cells was monitored using Flow cytometry and Cytometric Beads Array. Expansion of CMV-specific T cells secreting gamma-interferon as well as increase of total IFN-gamma and TNF-alfa; production could be detected after in vitro stimulation with CyaA-CMV constructs, while limited activation of T cells occurred with free peptides. No immune response was evoked by control CyaA without CMV antigenic peptides. These data reveal the potential of CyaA constructs as a tool for fast and reliable detection of CMV-specific immunity and for immunoprophylactic, as well as immunotherapeutic application against CMV-associated diseases in immunocompromised patients. ER -
JELÍNEK, Jiří, Irena ADKINS, P. ŠEBO a Jaroslav MICHÁLEK. In vitro activation of CMV-specific human CD8+ T cells by CyaA toxoids delivering pp65 epitopes. In \textit{1st International Conference on Advances in Cell and Gene Therapy and Immunotherapy: from basic research to clinical applications and 3rd Workshop on Immunotherapy.}. 2010. ISBN~978-80-7392-137-8.
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