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@inproceedings{907863,
author = {Šimara, Pavel and Stejskal, Stanislav and Peterková, Martina and Krontorád Koutná, Irena and Ráčil, Zdeněk and Mayer, Jiří},
address = {Brno, Česká Republika},
booktitle = {Advances in Molecular and Cancer Biology, 2010},
keywords = {CML; imatinib; CD34+; pCrkL; flow cytometry},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Brno, Česká Republika},
isbn = {978-80-210-5312-0},
pages = {43-45},
publisher = {muni PRESS},
title = {Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry},
year = {2010}
}
TY - JOUR
ID - 907863
AU - Šimara, Pavel - Stejskal, Stanislav - Peterková, Martina - Krontorád Koutná, Irena - Ráčil, Zdeněk - Mayer, Jiří
PY - 2010
TI - Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry
PB - muni PRESS
CY - Brno, Česká Republika
SN - 9788021053120
KW - CML
KW - imatinib
KW - CD34+
KW - pCrkL
KW - flow cytometry
N2 - Imatinib is a tyrosine kinase inhibitor nowadays used as a first line therapy for newly diagnosed chronic myeloid leukaemia (CML) patients. However, some of the patients relapse after initially good response. Therefore, reliable methods for predicting of the imatinib treatment response are sought. In our research we determine the level of phosphorylated CrkL protein, known as a substrate of Bcr-Abl, by flow cytometry. Its potential predictive value as a marker of imatinib treatment response will be assessed in the monuclear cells or CD34+ cells of peripheral blood samples of new CML patients.
ER -
ŠIMARA, Pavel, Stanislav STEJSKAL, Martina PETERKOVÁ, Irena KRONTORÁD KOUTNÁ, Zdeněk RÁČIL and Jiří MAYER. Determination of pCrkL level in chronic myeloid leukaemia cells using flow cytometry. In \textit{Advances in Molecular and Cancer Biology, 2010}. Brno, Česká Republika: muni PRESS, 2010, p.~43-45. ISBN~978-80-210-5312-0.
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