Low-level copy number changes of MYC genes have a prognostic
impact in medulloblastoma

J 2011

Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma

ZITTERBART, Karel; Hana FILKOVÁ; Lenka TOMÁŠIKOVÁ; Eva NEČESALOVÁ; Iva ZAMBO et. al.

Basic information

Original name

Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma

Authors

ZITTERBART, Karel (203 Czech Republic, guarantor, belonging to the institution); Hana FILKOVÁ (203 Czech Republic, belonging to the institution); Lenka TOMÁŠIKOVÁ (703 Slovakia, belonging to the institution); Eva NEČESALOVÁ (203 Czech Republic, belonging to the institution); Iva ZAMBO (203 Czech Republic, belonging to the institution); Dagmar KANTOROVÁ (203 Czech Republic, belonging to the institution); Iva SLÁMOVÁ (203 Czech Republic, belonging to the institution); Vladimíra VRANOVÁ (703 Slovakia, belonging to the institution); Dita ŽEŽULKOVÁ (203 Czech Republic, belonging to the institution); Martina PEŠÁKOVÁ (203 Czech Republic, belonging to the institution); Zdeněk PAVELKA (203 Czech Republic, belonging to the institution); Renata VESELSKÁ (203 Czech Republic, belonging to the institution); Petr KUGLÍK (203 Czech Republic, belonging to the institution) and Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution)

Edition

Journal of Neuro-Oncology, Springer Netherlands, 2011, 0167-594X

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Netherlands

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 3.214

RIV identification code

RIV/00216224:14110/11:00051527

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.1007/s11060-010-0289-3

UT WoS

000287504400004

Keywords in English

medulloblastoma; amplification; gain; MYCN; MYCC; I-FISH

Abstract

In the original language

Analysis of a cohort of 29 medulloblastoma patients has clearly shown that copy number increases of MYC genes (MYCC, MYCN)are associated with lowered event-free survival and overall survival in MB. In the case of MYCN, this negative correlation was statistically significant.

Cite

ZITTERBART, Karel; Hana FILKOVÁ; Lenka TOMÁŠIKOVÁ; Eva NEČESALOVÁ; Iva ZAMBO; Dagmar KANTOROVÁ; Iva SLÁMOVÁ; Vladimíra VRANOVÁ; Dita ŽEŽULKOVÁ; Martina PEŠÁKOVÁ; Zdeněk PAVELKA; Renata VESELSKÁ; Petr KUGLÍK and Jaroslav ŠTĚRBA. Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma. Journal of Neuro-Oncology. Springer Netherlands, 2011, vol. 102, No 1, p. 25-33. ISSN 0167-594X. Available from: https://doi.org/10.1007/s11060-010-0289-3.

@article{908112,
   author = {Zitterbart, Karel and Filková, Hana and Tomášiková, Lenka and Nečesalová, Eva and Zambo, Iva and Kantorová, Dagmar and Slámová, Iva and Vranová, Vladimíra and Žežulková, Dita and Pešáková, Martina and Pavelka, Zdeněk and Veselská, Renata and Kuglík, Petr and Štěrba, Jaroslav},
   article_number = {1},
   doi = {https://doi.org/10.1007/s11060-010-0289-3},
   keywords = {medulloblastoma; amplification; gain; MYCN; MYCC; I-FISH},
   language = {eng},
   issn = {0167-594X},
   journal = {Journal of Neuro-Oncology},
   title = {Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma},
   volume = {102},
   year = {2011}
}

TY  - JOUR
ID  - 908112
AU  - Zitterbart, Karel - Filková, Hana - Tomášiková, Lenka - Nečesalová, Eva - Zambo, Iva - Kantorová, Dagmar - Slámová, Iva - Vranová, Vladimíra - Žežulková, Dita - Pešáková, Martina - Pavelka, Zdeněk - Veselská, Renata - Kuglík, Petr - Štěrba, Jaroslav
PY  - 2011
TI  - Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma
JF  - Journal of Neuro-Oncology
VL  - 102
IS  - 1
SP  - 25-33
EP  - 25-33
PB  - Springer Netherlands
SN  - 0167594X
KW  - medulloblastoma
KW  - amplification
KW  - gain
KW  - MYCN
KW  - MYCC
KW  - I-FISH
N2  - Analysis of a cohort of 29 medulloblastoma patients has clearly shown that copy number increases of MYC genes (MYCC, MYCN)are associated with lowered event-free survival and overall survival in MB. In the case of MYCN, this negative correlation was statistically significant.
ER  -

ZITTERBART, Karel; Hana FILKOVÁ; Lenka TOMÁŠIKOVÁ; Eva NEČESALOVÁ; Iva ZAMBO; Dagmar KANTOROVÁ; Iva SLÁMOVÁ; Vladimíra VRANOVÁ; Dita ŽEŽULKOVÁ; Martina PEŠÁKOVÁ; Zdeněk PAVELKA; Renata VESELSKÁ; Petr KUGLÍK and Jaroslav ŠTĚRBA. Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma. \textit{Journal of Neuro-Oncology}. Springer Netherlands, 2011, vol.~102, No~1, p.~25-33. ISSN~0167-594X. Available from: https://doi.org/10.1007/s11060-010-0289-3.

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