NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ a Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. General Physioogy and Biophysics. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, roč. 29, č. 4, s. 381-389. ISSN 0231-5882. |
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@article{911684, author = {Nováková, Marie and Sedláková, Barbora and Sirová, Marta and Fialová, Kateřina and Križanová, Olga}, article_location = {Bratislava}, article_number = {4}, keywords = {haloperidol; sigma receptor; IP3 receptor}, language = {eng}, issn = {0231-5882}, journal = {General Physioogy and Biophysics}, title = {Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles}, volume = {29}, year = {2010} }
TY - JOUR ID - 911684 AU - Nováková, Marie - Sedláková, Barbora - Sirová, Marta - Fialová, Kateřina - Križanová, Olga PY - 2010 TI - Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles JF - General Physioogy and Biophysics VL - 29 IS - 4 SP - 381-389 EP - 381-389 PB - INST OF MOLEC PHYSIOL GENETICS SLOVAK AC SN - 02315882 KW - haloperidol KW - sigma receptor KW - IP3 receptor N2 - Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles. ER -
NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ a Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. \textit{General Physioogy and Biophysics}. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, roč.~29, č.~4, s.~381-389. ISSN~0231-5882.
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