2010
Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte
PÁSEK, Michal; Jiří ŠIMURDA and Clive ORCHARDBasic information
Original name
Effect of BAPTA and EGTA on inactivation of ICa in a model of rat ventricular myocyte
Name in Czech
Účinek BAPTA a EGTA na inaktivaci ICa v modelu srdeční komorové buňky potkana
Authors
PÁSEK, Michal (203 Czech Republic, guarantor); Jiří ŠIMURDA (203 Czech Republic, belonging to the institution) and Clive ORCHARD (826 United Kingdom of Great Britain and Northern Ireland)
Edition
Analysis of Biomedical Signals and Images, 2010
Other information
Language
English
Type of outcome
Conference abstract
Field of Study
10610 Biophysics
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
RIV identification code
RIV/00216224:14110/10:00045971
Organization unit
Faculty of Medicine
ISBN
978-80-214-4105-7
Keywords in English
cardiac cell; BAPTA; EGTA; calcium current; quantitative model
Tags
International impact, Reviewed
Changed: 30/12/2012 18:04, doc. Ing. Michal Pásek, Ph.D.
Abstract
In the original language
An existing model of the rat ventricular myocyte was modified to reproduce the experimentally observed differential effects of the fast and slow exogenous Ca2+ buffers BAPTA and EGTA on inactivation of ICa and to investigate the possible cause. The results of the simulations suggest that the different potencies of EGTA and BAPTA on inactivation of ICa are due to their different rates of Ca2+ binding, and thus different intracellular gradients of bound and unbound buffer, causing different rates of diffusion of bound and unbound buffer out of and into the dyadic space. The consequent difference in suppression of the Ca2+ transient in the dyadic space caused different rates of Ca2+ - induced inactivation of ICa in the presence of the two buffers.
Links
| MSM0021622402, plan (intention) |
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