Time-resolved luminescence spectroscopy as a tool for study of reaction mechanisms

LUBAL, Přemysl, Jakub VANĚK, Petr HERMANN and Petr TÁBORSKÝ. Time-resolved luminescence spectroscopy as a tool for study of reaction mechanisms. In Abstract Book of XIV. International Symposium on Luminescence Spectrometry. Praha: Faculty of Pharmacy, Charles University, Prague, 2010, 216 pp. ISBN 978-80-254-6830-2.

Basic information

• Original name: Time-resolved luminescence spectroscopy as a tool for study of reaction mechanisms
• Authors: LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution), Petr HERMANN (203 Czech Republic, belonging to the institution) and Petr TÁBORSKÝ (203 Czech Republic, belonging to the institution).
• Edition: Praha, Abstract Book of XIV. International Symposium on Luminescence Spectrometry, 216 pp. 2010.
• Publisher: Faculty of Pharmacy, Charles University, Prague

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/10:00046189
• Organization unit: Faculty of Science
• ISBN: 978-80-254-6830-2
• Keywords in English: time-resolved luminescence spectroscopy; lanthanide(III) complexes; macrocyclic ligands; kinetics; reaction mechanism

Abstract

Ln(III) complexes of macrocyclic ligand H4dota and its derivatives are utilized in many areas of medicinal chemistry. Crucial factor for MRI and luminescence probes is determination of the number of the water molecules coordinated to Ln(III) complex, then its thermodynamic stability and kinetic inertness of the complexes. Time-resolved luminescence spectroscopy of Eu(III) ion and its complexes with macrocyclic DOTA-like ligands as model Ln(III) complexes in solutions for measurement of luminescence decay is used for the determination of the number of water molecules in the first coordination sphere. This measurement can be used for estimation of the number of coordinated water molecules in the course of Eu(III) complexation by ligands or Eu(III) complex dissociation in order to propose its reaction mechanism. The achieved results can be utilized for optimization of ligand structure for Ln(III) fast complexation/slow decomplexation.

Links

• LC06035, research and development project: Name: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.

Investor: Ministry of Education, Youth and Sports of the CR, Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine

• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)

• MUNI/A/0992/2009, interní kód MU: Name: Vývoj metodologie a instrumentace analytické chemie pro studium složení a vlastností přírodních a syntetických materiálů (Acronym: MIA)

Investor: Masaryk University, Category A

• OC 179, research and development project: Name: Molekulární zobrazování založené na systémech obsahujících kovy.