Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents

LUBAL, Přemysl, Jakub VANĚK, Romana ŠEVČÍKOVÁ, Miloslav POLÁŠEK, Petr HERMANN and Ivan LUKEŠ. Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents. In Abstract book of XIV. Symposium on Luminescence Spectrometry. Praha: Faculty of Pharmacy, Charles University Prague, 2010, 216 pp. ISBN 978-80-254-6830-2.

Basic information

• Original name: Ln(III) complexes of Mono(Pyridine-N-oxide) Analog of DOTA as a Potential Bimodal and Luminescence Imaging Agents
• Authors: LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution), Romana ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), Miloslav POLÁŠEK (203 Czech Republic), Petr HERMANN (203 Czech Republic, belonging to the institution) and Ivan LUKEŠ (203 Czech Republic, belonging to the institution).
• Edition: Praha, Abstract book of XIV. Symposium on Luminescence Spectrometry, 216 pp. 2010.
• Publisher: Faculty of Pharmacy, Charles University Prague

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 10406 Analytical chemistry
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/10:00046190
• Organization unit: Faculty of Science
• ISBN: 978-80-254-6830-2
• Keywords in English: Macrocyclic ligand; Ln(III) ions; thermodynamics; kinetics; photophysics; analytical determination

Abstract

Ln(III) complexes of H4dota and its derivatives are utilized in many areas of medicine. The molecular spectroscopy in UV/VIS region was employed to investigate chemical features of Eu(III)/Gd(III)/Tb(III) complexes of the title ligand in order to investigate their possible applications as bimodal agents. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. In the study of formation (pH = 5.0-6.0, t = 25 C, I = 0.1 M KCl) was found that the reactive species is HL 2- and the rate increases with decreasing ionic radius of the metal ions and it follows a trend along the Ln(III) series. The ligand capable of complex formation due show interesting photophysical properties to presence of chromophor/fluorophor group and it enables to determine the low concentration of Eu(III)/Tb(III) ions.

Links

• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)

• MUNI/A/0992/2009, interní kód MU: Name: Vývoj metodologie a instrumentace analytické chemie pro studium složení a vlastností přírodních a syntetických materiálů (Acronym: MIA)

Investor: Masaryk University, Category A

• OC 179, research and development project: Name: Molekulární zobrazování založené na systémech obsahujících kovy.