Mono(pyridine-N-oxide) analog of DOTA ligand as suitable sensor for Ln(III) ions

LUBAL, Přemysl, Jakub VANĚK and Petr HERMANN. Mono(pyridine-N-oxide) analog of DOTA ligand as suitable sensor for Ln(III) ions. In Abstract book of Spring ACS meeting 2010 -document Nr. 17777. 2010.

Basic information

• Original name: Mono(pyridine-N-oxide) analog of DOTA ligand as suitable sensor for Ln(III) ions
• Authors: LUBAL, Přemysl (203 Czech Republic, guarantor, belonging to the institution), Jakub VANĚK (203 Czech Republic, belonging to the institution) and Petr HERMANN (203 Czech Republic, belonging to the institution).
• Edition: Abstract book of Spring ACS meeting 2010 -document Nr. 17777, 2010.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10406 Analytical chemistry
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/10:00046467
• Organization unit: Faculty of Science
• Keywords in English: Macrocyclic ligand; Ln(III) ions; thermodynamics; kinetics; photophysics; analytical determination

Abstract

Ln(III) complexes of DOTA ligand and its derivatives are utilized in many areas of medicine (e.g. complexes of metal radioisotopes as 90Y, 153Sm, 166Ho, 177Lu in nuclear medicine, Gd(III) complexes as MRI contrast agents, Eu(III)/Tb(III) complexes as luminescent probes). In this contribution, the thermodynamic and kinetic properties of Ln(III) complexes (Ln = Ce, Eu, Gd, Yb) of the mono(pyridine-N-oxide) DOTA derivative were studied by molecular absorption and emission spectroscopies (in UV/VIS region, luminescence, TRFS) in order to investigate possible analytical application of title ligand. The stability constants and acid-assisted dissociation of Ln(III) complexes show high thermodynamic stability and kinetic inertness. Ln(III) complexes show interesting photophysical properties due to presence of chromophor/fluorophor group which enables to make sensor suitable for determination of low concentration of Eu(III)/Tb(III) ions.

Links

• ME09065, research and development project: Name: Výzkum nových detekčních systémů na bázi senzorových polí pro použití ve speciační analýze

Investor: Ministry of Education, Youth and Sports of the CR, Research of new detection systems based on sensor arrays for application in speciation analysis, Research and Development Programme KONTAKT (ME)

• OC 179, research and development project: Name: Molekulární zobrazování založené na systémech obsahujících kovy.