Imbalance in T-cell and cytokine profiles in patients with
relapsing-remitting multiple sclerosis

J 2011

Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK, Jaroslav MICHÁLEK et. al.

Základní údaje

Originální název

Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis

Autoři

MIKULKOVÁ, Zuzana (203 Česká republika, domácí), Petra PRAKSOVÁ (203 Česká republika), Pavel ŠTOURAČ (203 Česká republika), Josef BEDNAŘÍK (203 Česká republika) a Jaroslav MICHÁLEK (203 Česká republika, garant, domácí)

Vydání

Journal of the neurological sciences, Netherlands, Amsterdam : Elsevier, 2011, 0022-510X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.353

Kód RIV

RIV/00216224:14740/11:00051674

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.jns.2010.08.053

UT WoS

000286850900025

Klíčová slova česky

roztroušená skleróza; T lymfocyty; paměťové buňky; cytokiny; průtoková cytometrie

Klíčová slova anglicky

multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 4. 2012 14:19, Olga Křížová

Anotace

V originále

In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK a Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. Journal of the neurological sciences. Netherlands: Amsterdam : Elsevier, 2011, roč. 300, 1-2, s. 135-141. ISSN 0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2010.08.053.

@article{918900,
   author = {Mikulková, Zuzana and Praksová, Petra and Štourač, Pavel and Bednařík, Josef and Michálek, Jaroslav},
   article_location = {Netherlands},
   article_number = {1-2},
   doi = {http://dx.doi.org/10.1016/j.jns.2010.08.053},
   keywords = {multiple sclerosis; T-cells; memory cells; cytokines; flow cytometry},
   language = {eng},
   issn = {0022-510X},
   journal = {Journal of the neurological sciences},
   title = {Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis},
   volume = {300},
   year = {2011}
}

TY  - JOUR
ID  - 918900
AU  - Mikulková, Zuzana - Praksová, Petra - Štourač, Pavel - Bednařík, Josef - Michálek, Jaroslav
PY  - 2011
TI  - Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis
JF  - Journal of the neurological sciences
VL  - 300
IS  - 1-2
SP  - 135-141
EP  - 135-141
PB  - Amsterdam : Elsevier
SN  - 0022510X
KW  - multiple sclerosis
KW  - T-cells
KW  - memory cells
KW  - cytokines
KW  - flow cytometry
N2  - In the present study, T-lymphocyte populations and pro-inflammatory as well as suppressive cytokine profiles were evaluated in detail in previously untreated patients with relapsing-remitting multiple sclerosis (RRMS). CD4(+) and CD8(+) naive, central memory (Tcm), effector memory (Tem), terminal effector memory (Ttem), CD4(+) regulatory T-cells (Treg) and CD8(+) T-suppressor cells (Ts) were analysed using flow cytometry, and levels of ten plasma cytokines were determined using fluorescent bead-based immunoassay. We evaluated two groups of RRMS with minor (n=33) and major (n=25) clinical impairment and compared them with healthy controls (n=40) in order to detect any correlation between severity of MS clinical symptoms and immune disturbances. In conclusion, we demonstrate complex immune dysbalances in untreated MS patients.
ER  -

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK a Jaroslav MICHÁLEK. Imbalance in T-cell and cytokine profiles in patients with relapsing-remitting multiple sclerosis. \textit{Journal of the neurological sciences}. Netherlands: Amsterdam : Elsevier, 2011, roč.~300, 1-2, s.~135-141. ISSN~0022-510X. Dostupné z: https://dx.doi.org/10.1016/j.jns.2010.08.053.

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