The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus.

BALÁŽ, Marek, Hana SROVNALOVÁ, Irena REKTOROVÁ and Ivan REKTOR. The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus. Experimental Brain Research. Springer Verlag, 2010, 203/2010, No 2, 11 pp. ISSN 0014-4819.

Basic information

• Original name: The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus.
• Authors: BALÁŽ, Marek (703 Slovakia, guarantor, belonging to the institution), Hana SROVNALOVÁ (203 Czech Republic, belonging to the institution), Irena REKTOROVÁ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, belonging to the institution).
• Edition: Experimental Brain Research, Springer Verlag, 2010, 0014-4819.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.296
• RIV identification code: RIV/00216224:14110/10:00046774
• Organization unit: Faculty of Medicine
• UT WoS: 000277712500008
• Keywords in English: inferior frontal cortex; subthalamic nucleus; executive functions; ERP; P3; hyperdirect pathway

Abstract

We studied whether the cognitive event-related potentials (ERP) in the subthalamic nucleus (STN) are modified by the modulation of the inferior frontal cortex (IFC) and the dorsolateral prefrontal cortex (DLPFC) with repetitive transcranial magnetic stimulation (rTMS). Eighteen patients with Parkinson disease who had been implanted with a deep brain stimulation (DBS) electrode were included in the study. The ERPs were recorded from the DBS electrode before and after the rTMS (1 Hz, 600 pulses) over either the right IFC (10 patients) or right DLPFC (8 patients). rTMS over the right IFC led to a shortening of ERP latencies from 277 ms (SD) to 252 ms in the standard protocol and from 296 ms to 270 ms in the protocol modified by a higher load of executive functions. Connections (the IFC-STN hyperdirect pathway) with the cortex that bypass the BG-thalamocortical circuitries could explain the position of the STN in the processing of executive functions.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.