| WAGNER, Robert, Pavel PILER, Helena BEDÁŇOVÁ, Petr ADAMEK, Lucie GRODECKÁ a Tomáš FREIBERGER. Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial. Interactive CardioVascular and Thoracic Surgery. 2010, roč. 11, č. 6, 5 s. ISSN 1569-9293. |
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@article{919904,
author = {Wagner, Robert and Piler, Pavel and Bedáňová, Helena and Adamek, Petr and Grodecká, Lucie and Freiberger, Tomáš},
article_number = {6},
keywords = {Myocardial protection; Ischaemic preconditioning; Troponin I; Inducible nitric oxide synthases; Endothelial nitric oxide synthases},
language = {eng},
issn = {1569-9293},
journal = {Interactive CardioVascular and Thoracic Surgery},
title = {Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial},
volume = {11},
year = {2010}
}
TY - JOUR
ID - 919904
AU - Wagner, Robert - Piler, Pavel - Bedáňová, Helena - Adamek, Petr - Grodecká, Lucie - Freiberger, Tomáš
PY - 2010
TI - Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial
JF - Interactive CardioVascular and Thoracic Surgery
VL - 11
IS - 6
SN - 15699293
KW - Myocardial protection
KW - Ischaemic preconditioning
KW - Troponin I
KW - Inducible nitric oxide synthases
KW - Endothelial nitric oxide synthases
N2 - The purpose of this study was to test, whether the late phase of remote ischaemic preconditioning (L-RIPC) improves myocardial protection in coronary artery bypass grafting (CABG) with cold-crystalloid cardioplegia and whether preoperative tramadol modifies myocardial ischaemia-reperfusion injury using the same group of patients in a single-blinded randomized controlled study. One hundred and one adult patients were randomly assigned to either the L-RIPC, control or tramadol group. We found that L-RIPC can reduce injury beyond the myocardial protection provided by cold-crystalloid cardioplegia, and tramadol worsened myocardial injury after CABG. Expressions of iNOS were increased in the control (significantly) and L-RIPC groups and dampened in the tramadol group.
ER -
WAGNER, Robert, Pavel PILER, Helena BEDÁŇOVÁ, Petr ADAMEK, Lucie GRODECKÁ a Tomáš FREIBERGER. Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial. \textit{Interactive CardioVascular and Thoracic Surgery}. 2010, roč.~11, č.~6, 5 s. ISSN~1569-9293.
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