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@inproceedings{921129,
author = {Maláska, Jan and Kratochvíl, Milan and Kýr, Michal and Jabandžiev, Petr and Otevřel, Filip and Muriová, Katarína and Fedora, Michal and Šrámek, Vladimír and Ševčík, Pavel and Michálek, Jaroslav},
address = {Philadelphia},
booktitle = {Proceedings of the 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Selected Papers},
editor = {Faist, E},
keywords = {sepsis; multiorgan failure; Cytokines ; CRP; PCT; TREM-1; IL-6; IL-12; IL-4; IL-1 beta; TNF},
language = {eng},
location = {Philadelphia},
isbn = {978-88-6521-024-6},
pages = {33-37},
publisher = {Thomson Reuters},
title = {Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients},
year = {2010}
}
TY - JOUR
ID - 921129
AU - Maláska, Jan - Kratochvíl, Milan - Kýr, Michal - Jabandžiev, Petr - Otevřel, Filip - Muriová, Katarína - Fedora, Michal - Šrámek, Vladimír - Ševčík, Pavel - Michálek, Jaroslav
PY - 2010
TI - Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients
PB - Thomson Reuters
CY - Philadelphia
SN - 9788865210246
KW - sepsis
KW - multiorgan failure
KW - Cytokines
KW - CRP
KW - PCT
KW - TREM-1
KW - IL-6
KW - IL-12
KW - IL-4
KW - IL-1 beta
KW - TNF
N2 - During the progression of sepsis from early hit to multiorgan failure proinflammatory and anti-inflammatory cytokines are released. Cytokines can be used as biomarkers to determine the specific patterns of sepsis progression and association with mortality. In our study CRP levels correlated with the probability of survival, following levels of TREM-1, PCT and IL-6. Contrary to CRP and PCT levels, which rapidly fell during the first study days, levels of cytokines and TREM-I remained elevated throughout the study period, but were not so high and even normal in these subjects with severe sepsis despite early enrolment. Severity of disease at presentation correlated with levels of CRP, PCT, TREM-1, IL-6, IL-12, IL-4, IL-1 beta and TNF, especially in children. Response of circulating cytokines in patients with severe sepsis is heterogeneous in adults and children population and there is a specific pattern of this response related to mortality and severity at presentation. Furthermore, this pattern of response is different when comparing paediatric and adult patients.
ER -
MALÁSKA, Jan, Milan KRATOCHVÍL, Michal KÝR, Petr JABANDŽIEV, Filip OTEVŘEL, Katarína MURIOVÁ, Michal FEDORA, Vladimír ŠRÁMEK, Pavel ŠEVČÍK and Jaroslav MICHÁLEK. Cytokine response in severe sepsis - predicting the course of illness in adult and paediatric patients. In Faist, E. \textit{Proceedings of the 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Selected Papers}. Philadelphia: Thomson Reuters, 2010, p.~33-37. ISBN~978-88-6521-024-6.
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